BACKGROUND The study aimed to investigate the pharmacokinetics of intravenous ciprofloxacin and the adequacy of 400 mg every 12 hours in critically ill Intensive Care Unit (ICU) patients on continuous veno-venous haemodiafiltration (CVVHDF) with particular reference to the effect of achieved flow rates on drug clearance. METHODS This was an open prospective study conducted in the intensive ca...

The efficacy and therapeutic mechanisms of continuous renal replacement therapy (CRRT) for improvement of oxygenation in acute respiratory distress syndrome (ARDS) remain controversial. These questions were addressed by retrospective analysis of severe ARDS patients admitted to the pediatric intensive care unit of our hospital from 2009 to 2015 who received high-volume continuous veno-venous he...

Idiopathic pulmonary artery hypertension (IPAH) is a progressive disease with a dismal prognosis and lung transplantation is often the only option for patients, who do not respond to pharmacological therapy. We report the use of an extracorporeal membrane oxygenation (ECMO) system in a 49-year-old woman with primary pulmonary hypertension, previously liver transplanted. The patient, listed for ...

This report describes unusual clinical and pathological findings in a 29-yr-old female with pulmonary Langerhans' cell granulomatosis (LCG). During a 7-yr clinical course her condition deteriorated despite corticosteroid therapy, and she died of respiratory failure and pulmonary hypertension. At autopsy, there were widespread pulmonary veno-occlusive disease (PVOD) lesions as well as abundant a...

Within recent years there has been increasing interest in the presence of reversed flow through the ductus arteriosus. Most reported cases have been in older children and young adults. There is a group of cases in which the ductus serves as a site of a veno-arterial shunt in infancy, and thus continues to perform its fetal function. The conditions under which veno-arterial shunting persists aft...

Introduction. Rapid diagnosis of metformin-associated lactic acidosis (MALA) and initiation continuous renal replacement therapy (CRRT) in diabetic patient successfully corrects a severe metabolic disorder with acute failure. Case outline. A 58-year-old male medical history type 2 diabetes alcohol abuse was admitted to the Emergency Department because vomiting, diarrhea, altered mental status. ...

Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension that mainly affects children and young adults. Its cause is unknown, although viral infections and drugs have been implicated. Patients with PVOD present with symptoms of right-sided heart failure. Radiologic examination shows prominent pulmonary arteries with Kerley B lines, pleural effusion, and mediastinal aden...