In this paper, the researchers investigate the vegetative growth of Chromolaena odorata and the infl uence of light intensity on the understorey environment of Shorea robusta forest at Chitwan in south-central Terai, Nepal. C. odorata is a clonally growing shrub and typically consists of several clones with an underground “cormous organ” (a modifi ed stem to store food reserve; here after “corm...

Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased...

The Kv2.1 channel generates a delayed-rectifier current in neurons and is responsible for modulation of neuronal spike frequency and membrane repolarization in pancreatic β-cells and cardiomyocytes. As with other tetrameric voltage-activated K(+)-channels, it has been proposed that each of the four Kv2.1 voltage-sensing domains activates independently upon depolarization, leading to a final con...

Designing future computer networks dictates an eclectic vision capable of encompassing ideas and concepts developed in contemporary research unfettered by today’s operational and technological constraints. However, unguided by a clear articulation of core design principles, the process of network design may be at stake of falling into similar pitfalls and limitations attributed to current netwo...

In the present work, the inhibitory effect of carbon monoxide (CO), generated by tricarbonyldichlororuthenium (II) dimer [CO-releasing molecule (CORM-2)], on the toxicity of radiation-induced bystander effect (RIBE) after alpha-particle irradiation was studied in a mixed coculture system. CO (CORM-2) treatment showed a significant inhibitory effect to the formation of p53 binding protein 1 (BP1...

We examined our hypothesis that heme-oxygenase-1 (HO-1)-derived carbon monoxide (CO) inhibits the release of high-mobility group box 1 (HMGB1) in RAW264.7 cells activated with lipopolysaccharide (LPS) in vitro and in LPS- or cecal ligation and puncture (CLP)-induced septic mice in vivo, so that HO-1 induction or CO improves survival of sepsis in rodents. We found that pretreatment with HO-1 ind...

OBJECTIVE The aim of this study was to observe the counter-effect of carbon monoxide-releasing molecule-2 (CORM-2) on lipopolysaccharide (LPS)-suppressed thrombomodulin (TM) and endothelial protein C receptor (EPCR) expressions from human umbilical vein endothelial cell (HUVEC), and to reveal its mechanisms. METHODS HUVECs were divided into 5 treatment groups, wherein reagents were added simu...

Tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is specifically induced upon tissue injury and infection and during septic conditions. Carbon monoxide (CO) gas is known to exert various anti-inflammatory effects in various inflammatory diseases. However, the mechanisms underlying the effect of CO on TN-C-mediated inflammation are unknown. In the present study, we found that treat...

in recent years the use of organic and biological modifier as an environmental friendly replacement for chemical fertilizers has been used more. in order to study the effect of different levels of biological fertilizers and mushroom compost on flower yield and characteristics of saffron corms (crocus sativus l.), a split plot experiment based on rcbd design with three replications was conducted...

Aims: This study aimed to determine the effects of different cultivation practices on yield and characteristics saffron corm grown in field greenhouse conditions.Methods Results: Two sizes, with an average weight 12 g 6 g, were used as production material. The corms was carried out areas where 4 treatments applied such silt (fine stream sand), cockpeat, peat + perlite cockpeat perlite. Field st...