BACKGROUND The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell-cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell-related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell disease. METHODS In this double-blind, ran...

The Caucasus has seen numerous crises since the region gained independence following the collapse of the Soviet Union. Some of these crises have not been resolved yet as evidenced by recent Russia-Georgia conflict. This paper seeks to analyze such crises within the framework of significant geopolitical changes unfolded by the collapse of the Soviet Union. The author argues that in the post-Sovi...

This article will review the case of a young patient with mental retardation, autistic disorder, and Tourette Syndrome who exhibited a favourable treatment response preferentially to risperidone. His presentation, however, was complicated by an exquisite sensitivity to risperidone displayed in the form of recurrent oculogyric crises. In this article, we will outline a review of the case, a surv...

The paper studies the factors associated with the emergence of systemic banking crises in a sample of developed and developing countries in 1981-94 using a multivariate logit econometric model. The results show that a weak macroeconomic environment with low growth and high inflation makes crises more likely; high real interest rates have also contributed to banking sector fragility, and so does...

Are countries with unregulated capital flows more vulnerable to currency crises? Efforts to answer this question properly must control for self-selection bias, because countries with liberalized capital accounts may also have sounder economic policies and institutions that make them less likely to experience crises. We employ a matching and propensityscore methodology to address this issue in a...

This paper tests whether consumption pattern in Korea exhibits a time-inconsistent discounting behavior using a quasi-hyperbolic Euler equation estimated by the generalized method of moments (GMM). In particular, we examine whether consumers change their discounting behavior during financial crises in 1997 and 2008. The estimation results show that Korean consumers exhibit a time-inconsistent q...

In this article we provide a summary of empirical results obtained in several economics and operations research papers that attempt to explain, predict, or suggest remedies for financial crises or banking defaults, as well as outlines of the methodologies used. We analyze financial and economic circumstances associated with the US subprime mortgage crisis and the global financial turmoil that h...

This research develops an early warning system (EWS) for equity market crises based on multinomial logit models and variables relating to the information content of index futures and options. We show that the information impounded in S&P 500 futures and options are useful as leading indicators of financial crises. The current literature is absent of such studies. Results reveal that models esti...

A rapidly growing empirical literature is studying the causes and consequences of bank fragility in contemporary economies. The paper reviews the two basic methodologies adopted in cross-country empirical studies, the signals approach and the multivariate probability model, and their application to study the determinants of banking crises. The use of these models to provide early warnings for c...

Introduction :Vitamin D deficiency is associated with hypertension; however, there is no study on the relationship between vitamin D deficiency and hypertensive crises. This study aimed to determine the relationship between serum vitamin D levels and hypertensive crises. Materials and Methods: This descriptive-analytical, cross-sectional study was conducted on 120 individuals in Shafa Hospital ...