OBJECTIVE An early fetal growth lag may be a marker of future complications. We sought to determine the utility of early biometric variables in predicting adverse pregnancy outcomes. METHODS In this retrospective cohort study, the crown-rump length at 11 to 14 weeks and the head circumference, biparietal diameter, abdominal circumference, femur length, humerus length, transverse cerebellar di...

The aim of this study is to assess the association between crown-rump length (CRL) measured before the 10th gestational week and birth weight. Results from 316 transvaginal ultrasonography scans at the 46th, 53rd, 60th, 67th, and 74th days of pregnancy were compared in low birth weight (LBW) versus normal birth weight groups. A positive correlation between CRL and birth weight was observed when...

Timing of first appearance and subsequent distribution of adipose tissue were assessed in 488 normal-for-age human fetuses. The sample represented each of the three trimesters of normal pregnancies. Light microscopy showed that adipose tissue first appears and progressively develops from the 14th to 24th week of gestation (100-216 mm crown-rump length) in those areas where it characteristically...

The amount and development of cartilage in the lungs of 150 children dying between 24 week's gestation and 12 years has been studied using standard sections of the right middle lobe. Both the cartilage-bearing bronchi and the cartilage fragments increase in number until approximately two months after birth, after which time a constant level is maintained. There is a progressive increase in the ...

Nuchal translucency (NT) thickness is utilized as a screening test in prenatal assessment of risk of aneuploidy in the first trimester. This test is performed between 11.0-13.9 weeks gestational age, corresponding to a crown-rump length (CRL) of 45-84mm. Alone, or in combination with maternal serum analytes of pregnancy-associated plasma protein A (PAPP-A) and beta human chorionic gonadotropin ...

In vitro effects of bFGF on neural tube, heart, and total embryonic development were investigated in 60 rat embryos (obtained from seven pregnant females) at 9.5 days of gestation that were cultured in whole rat serum (WRS), in >30 kDa serum fractions [retenate (R)], and in R+bFGF. After 48 h culture, the embryos from each group were harvested and divided into two groups. One group was analysed...

Obtaining accurately staged rat embryos can be difficult because of the variety of breeding protocols employed and because precise staging cannot be confirmed until excision of the embryos from the dam. The detection of estrus, pairing of animals, and confirmation of pregnancies is generally left to commercial suppliers, as in-house breeding can be laborious and unpredictable. Here we describe ...