A series of symmetrical dimeric proton pump inhibitor (PPI) analogues, designed as novel type DNA minor groove binders, was synthesized and evaluated for anti-tumor activity. Some of these new compounds showed IC(50) values below 10 microM in an in vitro anti-tumor test. A molecular modeling study was performed to confirm the sequence selectivity of these compounds towards AT base pairs in DNA....

BACKGROUND Minor surgery is a well-established part of family practice, but its safety and cost-effectiveness have been called into question. AIM To audit the performance of GP minor surgeons in three different settings. DESIGN AND SETTING A community-based surgery audit of GP minor surgery cases and outcomes from three settings: GPs who carried out minor surgery in their practice funded as...

The crystal structure of the self-complementary DNA octamer d(GGCATGCC) has been determined to a resolution of 2.38 A and R factor of 17.1%. The structure is an A-DNA octamer duplex with Watson-Crick base pairing along its length. This sequence extends the investigation of octamer duplexes of the type d(GGX(4)CC) which assume P6(1) packing within the crystallographic unit cell. The A-DNA duplex...

We present a new translation model that include undecorated hierarchical-style phrase rules, decorated source-syntax rules, and partially decorated rules. Results show an increase in translation performance of up to 0.8% BLEU for German–English translation when trained on the news-commentary corpus, using syntactic annotation from a source language parser. We also experimented with annotation f...

The minor crossing number of a graph G is the minimum crossing number of a graph that contains G as a minor. It is proved that for every graph H there is a constant c, such that every graph G with no H-minor has minor crossing number at most c|V (G)|.