Pericarditis/pericardial effusion (PC/PEEF) is a rare but fatal complication of cytosine arabinoside (Ara-C). We report an acute myeloid leukemia (AML) patient who developed massive pericardial effusion after a second Ara-C exposure. As Ara-C was most beneficial in controlling the leukemia, she was treated with a further cycle of Ara-C along with dexamethasone to prevent the complication from r...

Experiments were conducted to obtain additional insight into the response patterns of the intestinal crypts to 1-0-D-arabinofuranosylcytosine, a potent inhibitor of DNA synthesis. The results indicate that this interference with nucleic acid metabolism is not lethally toxic to the crypt epithelial cells. This formulation is based on the following observations: (a) the absence of definitive ultr...

Thirteen relapsed or refractory AML patients were treated with the FLA regimen. A complete remission was observed in 54% of cases but the median duration of remission was short (4 months). These results suggest that the FLA regimen is not able to induce a durable complete remission in the poor-risk AML patients.

Experiments were conducted to obtain additional insight into the response patterns of the intestinal crypts to 1-0-D-arabinofuranosylcytosine, a potent inhibitor of DNA synthesis. The results indicate that this interference with nucleic acid metabolism is not lethally toxic to the crypt epithelial cells. This formulation is based on the following observations: (a) the absence of definitive ultr...

The nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), does not induce heat-labile SV40 T antigen but does induce a previously uncharacterized heat-stable SV40 antigen-the SV40 "U" antigen. This antigen is detectable by both immunofluorescence and complement fixation by using sera from hamsters with SV40 tumors. Sera from hamsters bearing SV40 tumors can be divide...

Erythroid burst-promoting activity (BPA) is released from B lymphocytes in soluble (sBPA) and membrane-bound (mBPA) forms. To study intracellular processes involved in production of these physically separable factors, we measured their time course release into serum-free medium from B cells that were pulse-exposed for 5-240 min to nonmitogenic base medium or inhibitors of energy-dependent metab...