250 words) The vast majority of clinically-approved protein kinase inhibitors target the ATP binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify because allosteric binding sites are often unknown or poorly characterized, and there is ...

Nursing is a profession considered in the careers of public interest for Ecuadorian state, it largest labor force health system and interacts with user permanently 24 hours day, physical, emotional, psychological, spiritual areas. covers intramural extramural spaces develops activities promotion, prevention, healing, restoration life its essential competencies, direct care, management. The prop...

<p>Savings in an economy can assume one of the several forms. These includes: Personal savings, corporate savings or business and Government savings. This study evaluated growth impact on Nigerian economy. The specifically examined effect total private consumption expenditure, gross fixed capital formation core credit to sector domestic product Nigeria. Data for were sources from CBN stat...

This research proposes and discusses proper notions of risk and risk aversion for risks in the dimension of time, which are suitable for the analysis of time optimal decision making according to Burkhardt. The time optimal approach assumes a decision maker with a given goal, e.g. a given future wealth level, that he would like to reach as early as possible. To reach the goal, he can choose from...

Around 3 billion people in developing countries rely on woodfuels for their daily cooking needs with profound negative implications for their workload, health, and budget as well as the environment. Improved cookstove (ICS) technologies in many cases appear to be an obvious solution. Despite continuous eff orts of the international community to disseminate ICS, take up rates in most developing ...

Jailer of Freedom and Enemy of Growth? The Role of Personal and Social Identities in Educational Choices This paper develops a theoretical and empirical model on the influence of identity on educational choices which extends the existing literature in several directions. The theoretical model proposed here allows schooling choices to be independently influenced by both personal and social ident...

In this paper we study the corrective role of income taxation in a model with the Gul and Pesendorfer type of temptation and self-control preferences embedded with labor/leisure choice. “Excessive” impatience created by the presence of temptation in preferences causes a bias in favour of present consumption and a two-dimensional problem: under-saving and over-supply-of-labor. In such an environ...