Abstract Purpose The purpose of this single-centre, prospective, comparative study was to evaluate the pattern and severity brain structural changes in patients with resistant hypertension based on MRI assessments their one year after renal denervation. Material methods comprised 58 (RH), aged 52.1±9.1 years, who underwent denervation (RDN) according good clinical practice guidelines. Patients ...

Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases of multiple etiologies. Although great progress has been made, researchers are still working on the pathogenesis of T2DM and how to best use the treatments available. Aside from several novel pharmacological approaches, catheter-based sympathetic renal denervation (RDN) has gained a significant role in resistant hypertension, as w...

The renal nerves play a dominant role in blood pressure (BP) regulation. The intricate interplay between afferent sensory nerves, efferent sympathetic nerves, and modulatory influences mediated by mechanoand chemoreceptors render the renal nerves an attractive therapeutic target. Indeed, elegant experimental studies in a range of animal models and application of radiotracer dilution to assess s...

Adequate blood pressure control represents an important goal for all physicians due to the complications of hypertension which reduce patients' quality of life. A new interventional strategy to reduce blood pressure has been developed for patients with resistant hypertension. Catheter-based renal denervation has demonstrated excellent results in recent investigations associated with few side ef...

SUMMARY Denervation changes in muscle following damage to cranial and peripheral nerves can be observed on both CT and MR imaging studies. These findings are well described for cranial nerves (CN) V, X, XI, and XII. The CT findings of denervation atrophy due to CN VII dysfunction have been reported. We describe the MR imaging findings in two patients with perineural spread of tumor along CN VII...

INTRODUCTION: Several experimental studies suggest that growth hormone-based therapies have the potential to accelerate and augment axonal regeneration while simultaneously act directly on muscle and Schwann cells (SCs) to minimize denervation atrophy prior to re-innervation. The purpose of this study was to assess the impact of growth hormone (GH) therapy on preventing the deleterious effects ...

In order to study mechanisms of muscle denervation atrophy, a locomotor training on a treadmill was applied to denervated rat soleus muscle. Ultrastructure of the treated muscles were investigated two months after denervation. It has been found that pathological changes caused by denervation were less pronounced in trained muscle comparing to untrained muscle. For example, the number of capilla...

The renal sympathetic nerves have significant contribution to the control of different aspects of kidney function. Early animal studies of renal denervation in a large number of different models of hypertension showed that that RDN improved BP control. Recently, data from prospective cohorts and randomized studies showed that renal denervation therapy (RDN) is a safe procedure but is associated...

The mechanism underlying a phenomenon of such a general occurrence as the supersensitivity after denervation has often been attributed to a decrease of the enzyme cholinesterase in the tissues concerned. Different organs exhibit varying degrees of hypersensitivity; skeletal and smooth muscle, glands, autonomic ganglion cells and neurones of the spinal cord and brain all develop this post-denerv...

Denervation surgery has been a mainstay of our management of chronic pain in the wrist. If there is useful movement at the wrist we prefer denervation to arthrodesis. We have reviewed 22 patients at a mean of 50 months after such denervation surgery at the wrist. This was the only treatment in 16 patients; the other six also had other treatments. Pain was reduced in 16 patients, and 17 were sat...