a 53-year-old male was referred to our department for refractory primary hypertension. despite high doses of 6 anti-hypertensive drugs, ambulatory monitoring of blood pressure (bp) revealed a mean bp of 160/90 mmhg. under local anaesthesia, renal denervation with radiofrequency was performed supported by high-resolution 3d angiography, which helped confirm the position of the applications in a ...

Hypertension remains a major cause of cardiovascular morbidity and mortality globally. Difficulties faced by clinicians to obtain adequate blood pressure control in patients with resistant hypertension have led the development alternative device-based treatment methods, one which is renal artery denervation. In current paper, results study carried out Department Institute Cardiology regarding e...

The purpose of this single-centre, prospective, comparative study was to evaluate the pattern and severity brain structural changes in patients with resistant hypertension based on MRI assessments their one year after renal denervation. Material Methods. comprised 53 (RH), aged 52.1 ± 9.1 years, who underwent denervation (RDN) following Good Clinical Practice guidelines. Patients office blood p...

The seventh anniversary of the first catheter-based renal denervation procedure for resistant hypertension is near. At the “end of the beginning”, it is timely to reflect on the next phase in the development and clinical application of renal denervation in hypertension treatment. Unresolved procedural and technical questions are central: To what extent is renal denervation optimal? Is unilatera...

PURPOSE To illustrate and describe the appearance of both long-standing and relatively recently occurring motor denervation of the hypoglossal nerve and of the third (mandibular) division of the trigeminal nerve (V3), with emphasis on findings particular to MR imaging. METHODS Findings from 11 patients with V3 denervation and from seven patients with hypoglossal denervation resulting from a v...

Electric carotid baroreflex activation has been used to treat patients with resistant hypertension. It is hypothesized that, in conscious rats, combined activation of carotid baro- and chemoreceptors afferences attenuates the reflex hypotension. Rats were divided into 4 groups: (1) control group, with unilateral denervation of the right carotid chemoreceptors; (2) chemoreceptor denervation grou...

Re-evaluation of all functions of baroreflex by means of a simple mathematical model of circulation was the aim of the present study. The following states are modelled: 1. Rest. 2. Immediately after baroreceptor denervation. 3. Several days after denervation. 4. Physical exercise before denervation. 5. Physical exercise several days after denervation. Despite the same cardiac contractility and ...

The postsurgical period during which neurons remain without target connections (chronic axotomy) and distal nerve stumps and target muscles are denervated (chronic denervation) deleteriously affects functional recovery. An autologous nerve graft and cross-suture paradigm in Sprague Dawley rats was used to systematically and independently control time of motoneuron axotomy, denervation of distal...