We introduce a new multilevel domain decomposition method (MDD) for electronic structure calculations within semi-empirical and Density Functional Theory (DFT) frameworks. This method iterates between local fine solvers and global coarse solvers, in the spirit of domain decomposition methods. Using this approach, calculations have been successfully performed on several linear polymer chains con...

Accurate localization and tracking of facial features are crucial for developing high-quality model-based coding systems. In this paper we describe the integration of simple heuristics which are e!ective in improving the results of well-known facial feature detection with robust techniques for adapting a dynamic mesh for animation. A new method of generating a self-adaptive mesh using an extend...

We introduce a new multilevel domain decomposition method (MDD) for electronic structure calculations within semi-empirical and Density Functional Theory (DFT) frameworks. This method iterates between local fine solvers and global coarse solvers, in the spirit of domain decomposition methods. Using this approach, calculations have been successfully performed on several linear polymer chains con...

[Purpose] Chondrocytes in articular cartilage are aligned as columns from the joint surface. Notably, loss of chondrocyte and abnormalities of differentiation factors give rise to osteoarthritis (OA). However, the relationship between chondrocyte alignment and OA progression remains unclear. This study was performed to investigate temporal alterations in surgically-induced OA rats. [Subjects an...

A differential many-multiplet (DMM) technique is developed to probe the variability of α. Applied to the Fe ii lines of the metal absorption line system at z abs = 1.839 in the spectrum of Q1101–264 obtained by means of the UV-Visual Echelle Spectrograph (UVES) at the ESO Very Large Telescope (VLT), the DMM provides ∆α/α = (2.4 ± 3.8stat) × 10 −6. The z abs = 1.15 Fe ii system toward HE0515–441...

Intermediate Mass Black Holes (IMBHs; 10 M⊙) are thought to form as relics of Population III stars or from the runaway collapse of stars in young clusters; their number and very existence are uncertain. We ran N-body simulations of Galactic IMBHs, modeling them as a halo population distributed according to a Navarro, Frenk & White (NFW; 1996) or a more concentrated Diemand, Madau & Moore (DMM; ...

Deposition of amyloid is a common aging-associated phenomenon in several aging-related diseases. Osteoarthritis (OA) is the most prevalent joint disease, and aging is its major risk factor. Transthyretin (TTR) is an amyloidogenic protein that is deposited in aging and OA-affected human cartilage and promotes inflammatory and catabolic responses in cultured chondrocytes. Here, we investigated th...

This paper discusses the incorporation of dynamic memory management during High-Level-Synthesis (HLS) for effective resource utilization in many-accelerator architectures targeting to FPGA devices. We show that in today’s FPGA devices, the main limiting factor of scaling the number of accelerators is the starvation of the available on-chip memory. For many-accelerator architectures, this leads ...

Transforming growth factor beta 1 (TGF-β1) is implicated in osteoarthritis. We therefore studied the role of TGF-β1 signaling in the development of osteoarthritis in a developmental stage-dependent manner. Three different mouse models were investigated. First, the Tgf-β receptor II (Tgfbr2) was specifically removed from the mature cartilage of joints. Tgfbr2-deficient mice were grown to 12 mont...

In this paper, we present the development and validation of a Disaster Management Metamodel, a language that we develop specific for describing disaster management domain, as a foundational component to create a decision support system to unify, facilitate and expedite access to disaster management expertise. The metamodel which consists of four views based on disaster management phases includi...