OBJECTIVE: Social belief and experimental evidences indicate that opium and its alkaloids, morphine, produced hypoglycemic effects in animal models. This study was conducted in order to determine the role of morphine on blood glucose and insulin. MATERIAL AND METHODS: This is an empirical analysis investigating the laboratory albino male rats weighing 200-250 g. Rats in the control group recei...

Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...

PurposeTo study the effects of density folic acid (FA) on hypoglycemic ability FA-targeted polymersomes as oral insulin carriers. Also to change effect mixed added with various mass ratio d-α-tocopherol polyethylene glycol 1000 succinate (TPGS).MethodsThe different FA molar contents were prepared. The in vitro release experiments media for studied. Their quantitative cellular uptake Caco-2 cell...

Objective: Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome (PCOS) patients. There are various reports about hypoglycemic and antioxidant effects of Salvia officinalis L. (common sage). This study evaluated the possible medicinal effects of sage tea drinking on oxidative status, lipid profile, and insulin resistance in ...

In this study, the effects of late gestational undernutrition (LGU) on plasma concentration of insulin-like growth factor 1 (IGF-I), leptin, insulin and glucose in subsequent sucking lambs was investigated. Ten twin-bearing ewes were fed either restrictedly (Restricted) or adequately (Control) during the last six weeks of gestation and were fed ad libitum after parturition. Blood samples were t...

Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of tran...

Background: Poly cystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. The role of insulin-resistance (IR) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. N acetyl cysteine (NAC) ...

A SYSTEMATIC REVIEW AND META-ANALYSIS ON THE EFFECTS OF ENDURANCE TRAINING GROWTH HORMONE INSULIN-LIKE FACTOR-1 IN CHILDREN ADOLESCENTS