BACKGROUND We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these typical micro-opioid protein-(MOP) receptor effects. M...

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Dolilur Rahman1, Israt Jahan2, Shahid Uddin3, Zakir Uddin4, Shofiqul Islam5 and Monoarul Haque6* 1East-West Medical College, Bangladesh 2Department of Physiotherapy, East-West Medical College Hospital, Bangladesh 3Consultant of Medicine & Cardiology, Bangladesh 4Department of Medicine & Cardiology, Gono Bishwabidyalay, Bangladesh 5BIHS Diabetic Association, Bangladesh 6Department of Community N...

ii Dedication iii Acknowledgments iv Table of

Search for new therapeutic methods applied in psychiatric disorders, especially in depression--concern not only pharmacotherapy, but also physical techniques. Electroconvulsive treatment is a recognised and effective method for receiving of antidepressant effects by means of electric head stimulation with eliciting of seizures. During two past decades, a few new techniques using the electrical ...

Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of membrane electric potential cell behaviour. A related new viewpoint is introduced, with design photobiomodulation treatment restore part visual field. Here, first step experimental evidence validity developed. This result represents starting point for future improvements light stimula...

Electric carotid baroreflex activation has been used to treat patients with resistant hypertension. It is hypothesized that, in conscious rats, combined activation of carotid baro- and chemoreceptors afferences attenuates the reflex hypotension. Rats were divided into 4 groups: (1) control group, with unilateral denervation of the right carotid chemoreceptors; (2) chemoreceptor denervation grou...

We present experimental measurements and theoretical predictions of ion transport in agar gels during reversible electroporation (ECT) for conditions typical to many clinical studies found in the literature, revealing the presence of pH fronts emerging from both electrodes. These results suggest that pH fronts are immediate and substantial. Since they might give rise to tissue necrosis, an unwa...

Rehabilitation following total knee arthroplasty (TKA) is a costly, cumbersome, and often painful process. Physical therapy contributes to the successful outcome of TKA but can be expensive. Alternative methods of obtaining good functional results that help minimize costs are desirable. Neuromuscular electrical stimulation (NMES) is a potential option. Neuromuscular electrical stimulation has b...

BACKGROUND Electrotherapy is a relatively well established and efficient method of tumor treatment. In this paper we focus on analytical and numerical calculations of the potential and electric field distributions inside a tumor tissue in a two-dimensional model (2D-model) generated by means of electrode arrays with shapes of different conic sections (ellipse, parabola and hyperbola). METHODS...