Introduction: Considering high prevalence of epileptic disease and considering that 40 percent of epileptic patients are resistant to drug therapy, it needs more researches to find new therapeutic ways. LFS is among the new methods for epilepsy treatments. One possible mechanism involved in the anticonvulsant effect of LFS is increased adenosine. Therefore, in this study the role of adenosin...

OBJECTIVE AND DESIGN Peripheral neuropathy is a devastating uremic complication that causes debilitating pain and movement limitation. The aim of the study was to assess the influence of high-tone external muscle stimulation (HTEMS) therapy on clinical and electrophysiologycal parameters in hemodialysis patients with uremic peripheral neuropathy. PATIENTS AND INTERVENTIONS The study group con...

Atrial fibrillation (AF) is a disorder of the rhythm of electrical activation of the cardiac atria. It is the most common cardiac arrhythmia, has multiple aetiologies, and increases the risk of death from stroke. Pharmacological therapy is the mainstay of treatment for AF, but currently available anti-arrhythmic drugs have limited efficacy and safety. An improved understanding of how anti-arrhy...

BACKGROUND Machado-Joseph disease (MJD) is a dominantly inherited cerebellar ataxia associated with spasticity, ophthalmoplegia and dystonia. There has been no report of electrophysiological or histological alterations of the peripheral nervous system in patients with MJD. METHODS Four patients with MJD were identified by polymerase chain reaction. The peripheral nerves of these patients were...

In layer V pyramidal neurons, neurons that project across the corpus callosum have different electrophysiological properties compared to neurons that project down to the pons. Hyperpolarization activated cyclic nucleotide gated (HCN) channels are thought to be the basis of this difference. Characterizing how HCN channel influence these electrophysiological differences may be key in determining ...

Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery. As human pluripotent stem cell-derived cardiomyocytes remain functionally fetal-type, close monitoring of electrophysiological maturation is critical for their further application to biology and translation. However, to date, electrophysiologic...

Using the ARGUS detector at the e+e storage ring DORIS II, we have measured the Michel parameters , , and for ! l  decays in -pair events produced at center of mass energies in the region of the resonances. Using ! as spin analyzing tags, we nd e = 0:68 0:04 0:08, e = 1:12 0:20 0:09, e = 0:57 0:14 0:07, = 0:69 0:06 0:08, = 1:25 0:27 0:14 and = 0:72 0:18 0:10. In addition, we report the combine...

In the presence of nuisance parameters, we derive an explicit higher order asymptotic formula to compare the expected lengths of conndence intervals given by likelihood ratio statistics arising from the usual proole likelihood and various adjustments thereof. Highest posterior density regions, with approximate frequentist validity, are also included in the study.

AF leads to electrophysiological changes, but it is not known if similar alterations also appear before the onset of the first episode of AF because invasive electrophysiological studies are not justified in otherwise symptom-free patients. To address this question requires a safe method of obtaining atrial electrophysiological parameters at no extra risk or discomfort for the patient. The aim ...

The behavior of neural circuits is determined largely by the electrophysiological properties of the neurons they contain. Understanding the relationships of these properties requires the ability to first identify and catalog each property. However, information about such properties is largely locked away in decades of closed-access journal articles with heterogeneous conventions for reporting r...