We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, preserved after transformation. The NPs are assembled (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monobl...

La Unidad Vecinal n.° 3 (UV3) fue un planteamiento de vivienda social basado en la teoría Neighborhood-Unit y Ciudad-Satélite, donde los Espacios Libres Planificados (ELP) fueron relevantes para salubridad el desarrollo comunitario población, por lo que ocupados sus características físico-arquitectónicas transformadas; objetivo esta investigación identificar transformación apropiación ELP UV3. ...

The elongator (ELP) complex consisting of Elp1-6p has been indicated to play roles in multiple cellular processes. In yeast, the ELP complex has been shown to genetically interact with Uba4p/Urm1p and Kti11-13p for a function in tRNA modification. Through a Caenorhabditis elegans genetic suppressor screen and positional cloning, we discovered that loss-of-function mutations of moc-3 and dph-3, ...

BACKGROUND Use of petroleum-based over the counter remedies such as Vicks VapoRub to alleviate symptoms of rhinitis is common and can be effective, but carries under-appreciated risks of adverse side effects. In this case report we highlight Exogenous Lipoid Pneumonia (ELP), an uncommon condition that results from accumulation of exogenous lipids in the alveoli, as an adverse side effect of lon...

Abstract Introduction and objectives Exogenous lipoid pneumonia (ELP) is a lung inflammatory disease with low prevalence has the feature of external lipid substances presented in alveoli. Therapeutic lavage (segmental bronchoalveolar whole lavage) been gradually recognized as an important therapy for disease. There was no comprehensive summary on its efficacy safety. Methods We searched PubMed,...

SIMMONS, DAVID J., AND GEORGE NICHOLS, JR. Diurnal periodicity in the metabolic activity of bone tissue. Am. J. Physiol. LO(Q): 411-418. 1966. -Studies of the metabolism of bone cells in the metaphyses of the rat femur (distal) and tibia (proximal) have established that collagen synthesis and new bone formation is diurnally regulated. Significantly greater amounts of glycine-Q-Cl4 were initiall...

In industry, typical scheduling systems rely on production rates which are, in general, highly static. This is the case for capital intensive enterprises but not the case in labour intensive situations. On the other hand, while most, if not all, researchers will agree that using Genetic and Evolutionary Programming (GEP) to achieve optimal solutions in Job-Shop Scheduling Problems (JSSPs) in no...

We extend our previous analyses of mice deficient in selectins by describing the generation and comparative phenotype of mice lacking one, two, or three selectins after sequential ablation of the murine genes encoding P-, E-, and L-selectins. All mice deficient in selectins are viable and fertile as homozygotes. However, mice missing both P- and E-selectins (PE(-/-)), and mice missing all three...

We report a new thermal targeting method in which a thermally responsive drug carrier selectively accumulates in a solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. We synthesized two thermally responsive polymers that were designed to exhibit a lower critical solution temperature (LCST) transition slightly above physiological temperatur...

The orphan nuclear receptor, steroidogenic factor-1 (SF-1), plays an important role in the development of the adrenal gland and in sexual differentiation. SF-1 regulates the transcription of variety of genes, including several steroidogenic enzymes, Müllerian inhibiting substance, and gonadotropin genes. In this report, we sought to identify domains in SF-1 that are required for transactivation...