The cover image is based on the Research Article Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor-positive breast cancer by Heather M. Brechbuhl et al., https://doi.org/10.1002/mc.23377.

Objective: To analyze the scientific evidence from studies on effectiveness of immunomodulation in cancer. Methodology: This is a systematic review that searched for respective databases such as Pubmed, Scopus, Cinahl, Web Science, and The Cochrane Data Base, using descriptors English, selected Medical Subject Headings- MeSH. Soon after cataloging, were analyzed through Consolidated Standards R...

This is not the definitive version of record of this article. This manuscript has been accepted for publication in Endocrine Related Cancer, but the version presented here has not yet been copy edited, formatted or proofed. Consequently, the Society for Endocrinology accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at

The improvements in long-term breast cancer–related outcomes in recent decades, including disease-free and overall survival, are attributed to both early screening and optimal multidisciplinary therapy. Traditionally, women undergo a definitive surgical procedure—generally a mastectomy or a lumpectomy with axillary lymph node assessment—to allow for accurate pathologic staging. Because adjuvant...

Background: Thyroid cancer is the most common endocrine malignancy. Several risk factors were found to play a role in thyroid cancer. The purpose of the study was to determine the risk factors for thyroid cancer, in Babol, north of Iran. Method: 80 patients with thyroid cancer were selected as case group and 160 people living in the neighborhood of the patients as control group. Risk factors in...

Breast cancer affects Iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in Tehran. Thisstudy aimed to compare the AhR levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. Possible associations of AhR with lifestyle and reproductive risk factorsand ...

Breast cancer patients undergoing PET/CT scans for neoadjuvant systemic therapy may have non-breast (BC) related finding. The aim of this study is to describe the incidence, additional work-up and possible impact these findings. We included BC who underwent a scan in our institute between 2011-2019 prior therapy. An finding was defined as non-physiologic abnormal lesion only depicted by PET/CT....

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

Background Multiple Endocrine Neoplasia type 1 is a rare genetic syndrome mainly caused by mutations of MEN1 gene and characterized combination several endocrine non-endocrine manifestations. The objective this study was to describe cutaneous lesions other manifestations in cohort patients with familial (F) sporadic (S) , compare the prevalence these between two cohorts, investigate correlation...