γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesize...

In this research, a green, operationally simple, highly efficient and facile cascade Biginelli reaction using various aromatic aldehydes, ethyl acetoacetate, and urea/thiourea has been developed. First, the ionic liquid was prepared from the reaction of 1-methyl-2-pyrolidone with methane sulfonic acid. Then, this ionic liquid was applied as an acidic catalyst in the synthesis of dihydropyrimidi...

Overexpression of mutant p53 in cancer cell inactivates the pathways to execute apoptosis and cycle arrest. This study aimed synthesize new kardiena derivative compound, 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one, reactivate Characterization synthetic compound employing melting point, IR, EI-MS, 1H-NMR, 13C-NMR spectra revealed 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-...

In this paper, an environmentally benign access to synthesize Bis(pyrazol-5-ol) derivatives was developed through the one pot pseudo five component condensation reaction of phenyl hydrazine with ethyl acetoacetate, and different aryl/heteroaryl aldehydes using morpholinium glycolate as the homogeneous reusable catalyst under solvent-free conditions at 80 °C. Further, the ionic liquid was prepar...

Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free condition. This new protocol for Biginelli reaction has important advantages such as green synthesis, short reaction time, easy isolation and high yields of ...

An efficient one pot multi component synthesis of 1, 4-Polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction using lanthanum chloride heptahydrate (LaCl3.7H2O) from an aromatic aldehyde, ethyl acetoacetate, dimedone and ammonium acetate as a nitrogen precursor in ethanol at room temperature is described. In the present work we report lanthanum chloride heptahydrate remarkably n...

In this paper, an environmentally benign access to synthesize Bis(pyrazol-5-ol) derivatives was developed through the one pot pseudo five component condensation reaction of phenyl hydrazine with ethyl acetoacetate, and different aryl/heteroaryl aldehydes using morpholinium glycolate as the homogeneous reusable catalyst under solvent-free conditions at 80 °C. Further, the ionic liquid was prepar...

An efficient, mild and environmentally friendly method was reported for the synthesis of An efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of Methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These synth...