PURPOSE To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. MATERIALS AND METHODS A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the o...

NFkB transcription factors play a key role in the survival and proliferation of many kinds of B-cell tumors, including multiple myeloma (MM). It was shown that NFkB activation in MM tumors results mainly from extrinsic signaling by APRIL and BAFF ligands that stimulate receptors on normal plasma cells as well as on pre-malignant monoclonal gammopathy of undetermined significance (MGUS) and MM t...

Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to control cell proliferation or in response to DNA damage. The understanding of apoptosis has provided the basis for novel targeted therapies that can induce death in cancer cells or sensitize them to established cytotoxic agents and radiation therapy. These novel agents include those targeting the extrinsic pathw...

Background: While air travel is a well-established risk factor for venous thrombosis, the underlying mechanism is still incompletely understood. We previously demonstrated coagulation activation during air travel in healthy individuals, as assessed by a rise in thrombin-antithrombin complexes. It has been suggested that venous thrombosis is initiated via the extrinsic pathway of coagulation, sp...

considerable attention has been given to the identification of key forms of reward and its linkage to employee engagement. for this purpose following study aims to uncover the influence of extrinsic and intrinsic rewards on employee engagement in the public sector of uganda. a sample of 184 public sector employees was randomly selected and taken from gulu district. a quantitative approach based...

Cellular heterogeneity, which plays an essential role in biological phenomena, such as drug resistance and migration, is considered to arise from intrinsic (i.e., reaction kinetics) and extrinsic (i.e., protein variability) noise in the cell. However, the mechanistic effects of these types of noise to determine the heterogeneity of signal responses have not been elucidated. Here, we report that...