نتایج جستجو برای: familial adenomatous polyposis
تعداد نتایج: 64354 فیلتر نتایج به سال:
background: familial adenomatous polyposis (fap) is a well-known entity for specialistrnand it has near 100% chance of malignant changes if does not managed surgically. in orderrnto reduce the disadvantages of laparatomy and diverting ileostomy we present ourrnresults of laparoscopic total proctocolectomy without diverting ileostomy.rnobjectives: the aim of this study was to present the results...
Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC gene, the MYH polyposis is an autosomal recessive disease. The identification of individuals aff...
gardner’s syndrome is a genetic condition demonstrating an autosomal dominant trait and characterized by the multiple colonic polyps (familial adenomatous polyposis coli) with sebaceous cysts and jaw osteomas. various dental abnormalities present in patient’s suffering with this syndrome includes multiple impacted or unerupted teeth, supernumerary teeth, hypodontia, compound odontomes and denti...
Cyclooxygenase-2 (COX-2), the inducible COX isozyme, plays a key role in intestinal tumorigenesis. We have demonstrated recently that COX-2 protein is induced in the polyp stroma near the intestinal luminal surface in the Apc(Delta716) mouse, a model for human familial adenomatous polyposis, and stimulate tumor angiogenesis. However, the precise cell types that express COX-2 are still to be det...
Familial adenomatous polyposis ia an autosomal dominant disorder that is responsible for 0.5% of all colorectal cancer. Patients will develop hundreds to thousands of colonic polyp in their second decades of life. The life time risk of developing colorectal cancer is 100% at the median age of 39 years. Extra intestinal manifestations are rare and mostly are benign. Family history of colorectal ...
Background and Objectives: Familial adenomatous polyposis (FAP) is an inherited disorder and a rare form of colorectal cancer. This disease appears equally in both sexes and its occurrence is more in the second or third decade of life. Mutations and alterations of the mitochondrial genome, especially the D-loop region, have been reported in various human tumors. But the exact role of these muta...
BACKGROUND Duodenal adenomas develop in patients with familial adenomatous polyposis, incurring a risk of carcinoma. When this risk is high, surgery is indicated. The choice of surgical treatment can be difficult as evidence-based data are lacking. METHODS This is a systematic review of the literature on the non-medical management of duodenal lesions arising in the setting of familial adenoma...
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome leading to colorectal cancer. This disease appears as a result of germline mutation in adenomatous polyposis coli (APC) gene. The aim of the present study is to report the association between two different nucleotide substitutions detected in a family with FAP. In the proband, p.His1172Gln (c.3516delT) was detected in exon 1...
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