Objective: The present study aimed to evaluate of antimigraine activity methanolic extract Abroma augusta L. leaves in laboratory animals. Methods: was evaluated against nitroglycerine (NTG, 10 mg·kg−1, i. p.) and bradykinin (BK, µg, intra-arterial) induced hyperalgesia rats. Rats were divided randomly into six groups: normal, control, standard (sumatriptan, 42 s. c.), (100,200 400 p. o.). In t...

There are controversial reports on the effect of diabetes on the pain threshold. We used male Wistar rats to see the effect of streptozotocin induced diabetes on the tail flick, vocalisation and vocalisation after discharge responses. These represent the spinal, lower brain stem and hypothalamic responses respectively. The effect of morphine in these parameters was studied for both the control ...

In the present study the effects of both CCK receptor agonists and antago­ nists on antinociception induced by morphine in the tail-flick test have been evalu­ ated. M orphine induced dose-dependent antinoci�eption in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-3...

Aim: The objective of the current study is to investigate the antinoceptive effect of Pentazocineon streptozotocininduced diabetic rats. Methods: Diabetes mellitus was induced by using streptozotocin, dose of 50mg/kg body weight through lateral tail vein injection. After 48 hours, rat with blood glucose range of 200–300mg were used for experiment. NPH – insulin was given by subcutaneous injecti...

Ingestion of placenta has previously been shown to enhance opiate-mediated analgesia (measured as tail-flick latency) induced either by morphine injection or by footshock. The present study was designed to test whether placenta ingestion would enhance the partly opiate-mediated analgesia produced by vaginal/cervical stimulation. Nulliparous Sprague-Dawley rats were tested for analgesia, using t...

OBJECTIVE(S) The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors. MATERIALS AND METHODS Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 µg / ra...

In this study, we investigated the feasibility of applying neural networks to understanding movement-based visual signals. Networks based on three different models were constructed, varying in their input format and network architecture: a Static Input model, a Dynamic Input model and a Feedback model. The task for all networks was to distinguish a lizard (Amphibolurus muricatus) tail-flick fro...