The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

Glyceryl ethers are present in most mammalian tissues (17, 21) but have until recently been isolated from only a few anaerobic microorganisms (1, 4, 8, 9). Recently, Kamio et al. (12) have shown that these lipids are present in a number of anaerobic soil microorganisms, and Meyer and Meyer (14) have reported alk-1'-enyl glyceryl ethers (plasmalogens) in Treponema pallidum (Reiter) isolated from...

In the previous paper (1) we described a sequence of events which led from the isolation of crystalline “acetal phospholipide” by Feulgen and Bersin, and the realization by Schmidt and coworkers that the properties of this compound differed from those of native plasmalogen, to the preparation of plasmalogen fractions in this laboratory which indicated the presence of a fatty acid ester residue ...

Microsomal enzymes from Ehrlich ascites tumors synthesized 0-alkyl glyceryl ethers from hexadecanol and dihydroxyacetone phosphate in the presence of ATP, CoA, and Mg++. Glyceryl ether synthesis occurred via the formation of 0-alkyldihydroxyacetone phosphate and O-alkyldihydroxyacetone. Although NADPH inhibited the initial reaction of dihydroxyacetone phosphate with fatty alcohol, it was requir...

High blood pressure is common during the acute phase of stroke and is associated with a poor outcome. However, the management of high blood pressure remains unclear. The 'Efficacy of Nitric Oxide in Stroke' trial tested whether transdermal glyceryl trinitrate, a nitric oxide donor that lowers blood pressure, is safe and effective in improving outcome after acute stroke. Efficacy of Nitric Oxide...