Three cases of exertional haemoglobinuria are described. So far, the cause of the underlying haemolysis in this condition has not been satisfactorily explained, but in the cases described, the haemoglobinuric episodes appeared to be related to traumatic damage to the soles of the feet. Experimental studies support the hypothesis that the intravascular haemolysis results from mechanical damage t...

In order to evaluate the protective effect of Scoparia dulcis L. (Scrophulariaceae), a medicinal plant known to have medico-magic power, different extracts were prepared by successive extraction with hexane (HE), chloroform (CE) and methanol (ME) and by a soaking in acetone (80%). These extracts were checked for their protective role against neuroinflammation and erythrocytes haemolysis. They e...

An 18 month old girl with an angiographically measured ductus of 4.5 mm underwent transcatheter occlusion of the persistent arterial duct with a 17 mm Rashkind umbrella and an occluding spring coil. Severe intravascular haemolysis developed 20 hours later. Significant residual ductal leakage was noted and the residual duct measured 6 mm. Previous underestimation might have been related to ducta...

1. Glomerular filtration, wate rconcentration and acid load tests, measurement of urinary protein and cell excretion rates, bacteriological examination of the urine, and analysis of the urinary amino acid content were carried out in eight patients with chronic intravascular haemolysis due to aortic valve replacement. 2. All results were normal except for a slight reduction in creatinine clearan...

People with the variants of glucose-6-phosphate dehydrogenase (GPD) deficiency common in the southern Chinese (Canton, B(-)Chinese, and Hong Kong-Pokfulam) have a moderate shortening of red-cell survival but no anaemia when they are in the steady state. With a cross-transfusion technique, primaquine, nitrofurantoin, and large doses of aspirin were found to aggravate the haemolysis while sulpham...

Background and Objectives The significance of antibodies to red blood cells (RBCs) is variable cannot be predicted solely by serological testing. A flow cytometry-based erythrophagocytosis assay was established using phorbol 12-myristate 13-acetate (PMA)-treated THP-1 RBCs labelled with PKH26 assess allo- autoantibodies RBCs. Materials Methods were differentiated into macrophage-like treatment ...