The phthalocyanines have recently been suggested as one of most effective possible sensitizers for photodynamic therapy and the blood viral inactivation. The further characterisation of the mechanism of human red blood cell lysis and membrane alterations upon photodynamic treatment in the presence of Zn-phthalocyanine was the aim of this study. It was found that there were (2.7+/-0.4).10(7) dye...

Fatal acute haemolysis occurred in a 65-year-old man undergoing regular home haemodialysis for terminal renal failure. Circumstantial evidence indicating that the haemolysis resulted from exposure to concentrated dialysis solution was supported by in-vitro studies. Frank haemolysis in blood samples occurred at a dilution of greater than or equal to 1/2 of dialysis fluid. Osmotic fragility tests...

Perkash, A., Nair, A., Bhorchi, R., and Walia, B. N. S. (1971). Archives of Disease in Childhood, 46, 45. Haemolytic anaemia in Indian childhood cirrhosis. Fifty-five patients with Indian childhood cirrhosis were investigated for the occurrence of haemolysis and for its possible underlying mechanisms. Increased haemolysis was present in 76°/o of patients, and was severe in 12%. The degree of an...

Abstract  Red blood cells (RBCs) from patients with sickle cell disease (SCD) lyse in deoxygenated isosmotic non-electrolyte solutions. Haemolysis has features which suggest that it is linked to activation of the pathway termed Psickle. This pathway is usually described as a non-specific cationic conductance activated by deoxygenation, HbS polymerisation and RBC sickling. The current work addre...

This paper describes a modification of the Wassermann test giving an improved standardization of the complement titration and of the haemolytic system which is suitable to the resources of a small laboratory. Advantage has been taken of the stability of complement preserved by the method of Richardson (1941), so that modern methods for the standardization of the haemolytic system can be include...

Introduction Haemolysis, elevated liver enzymes and low platelet count (HELLP syndrome) is a high-risk condition of pregnancy with potentially fatal outcomes for mother and baby. It is typically identified by the presence of haemolysis, elevated liver enzymes and low blood platelets (Curtin & Weinstein 1999). These symptoms put the mother at risk for complications such as liver Background: Haem...

The results obtained by radial haemolysis in the detection of antibodies to rubella virus compared well with those obtained by haemagglutination inhibition. Radial haemolysis is unaffected by non-specific inhibitors. The sera do not therefore require pretreatment and the results are less equivocal. Radial haemolysis appears to be as sensitive as immunofluorescence and floatation centrifugation....

Out of 20 patients with viral hepatitis whose glucose-6phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more seve...

AIM To examine in vitro the effects of brief contact with various infusion solutions on red blood cells from newborn infants, as occurs in the "waste" syringe during routine blood sampling from umbilical artery catheters. The mixture of blood and solution in the "waste" syringe is usually reinfused into the baby. Reinfused red blood cells may be damaged by the infusion solution. It is hypothesi...