Abstract Background Metabolomics studies in cancer epidemiology have mostly focused on single metabolite-cancer site associations. Pan-cancer analyses may larger statistical power when identifying metabolites showing consistent associations across sites, while allowing the identification of site-specific Methods Data from seven cancer-specific case-control nested within European Prospective Inv...

Disrupted regulation of cellular processes is considered one of the hallmarks of cancer. We analyze metabolomic and transcriptomic profiles jointly collected from breast cancer and hepatocellular carcinoma patients to explore the associations between the expression of metabolic enzymes and the levels of the metabolites participating in the reactions they catalyze. Surprisingly, both breast canc...

Frequent loss of heterozygosity at chromosomal loci in a specific tumor type may indicate the presence of a tumor suppressor gene. We have examined loss of heterozygosity on chromosome 8p in paired tumor and constitutional DNA from 346 patients representing seven different types of human cancer. Frequent allelic losses were observed in hepatocellular carcinoma (22 of 46 cases, 47.8%), in colore...

Randomized clinical trials and actual practice differsignificantly. Evidence-based medicine develops new agents referring to, primarily, pharmaceutical findings, preclinical studies and, most importantly, randomized trials. Hepatocellular carcinoma is the common primary malignancy of liver, one main causes fatal outcomes among cancer patients worldwide, including in Asia-Pacific region, with an...

INTRODUCTION Previous studies indicate that the incidence of hepatocellular carcinoma in the United States is increasing. These reports, however, have contained limited information on population groups other than whites and blacks. METHODS We assessed recent incidence rates and trends for hepatocellular carcinoma by using newly available national data from cancer registries participating in t...

Abstract Background Hepatocellular carcinoma (HCC) is an increasingly common disease and classified as one of the most cancers leading to mortality worldwide. Only a small percentage patients with this are eligible curative treatment. Quite often main reason late diagnosis disease. In last decade, Nobel prize awarded discovery volatile organic compounds in breath opened frontiers for new diagno...

The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatoce...

BACKGROUND Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell proliferation. But hSulf-1 function is more complicated, and its molecular mechanism has not been well known. PRINCIPAL FINDINGS To further in...

To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H (high metastatic potential) and HepG2 (low metastatic potential), by reverse t...