Stroke is arguably the most feared cardiovascular event among healthy subjects and those with cardiovascular disease. Recent studies document changes in the epidemiology of stroke, both within and beyond the United States, which will impact medical service needs. Advances in our treatments for primary and secondary prevention herald an exciting period of change, which promises to lower stroke r...

In contrast to systolic heart failure (SHF), for which knowledge of pathophysiology and therapy has advanced rapidly over the past decade, little is known about diastolic heart failure (DHF). The article by van Heerebeek et al1 in this issue of Circulation that describes an abnormal distribution of titin isoforms in DHF may herald a new approach to understanding the pathophysiology of this synd...

Background: Various environmental factors can induce or exaggerate hand eczema. Objective: Evaluation of patch test results in hand eczema patients. Patients and Methods: In this descriptive study 100 patients with hand eczema referred to Loghman Hakim and Booali Hospital in Tehran underwent patch testing with 23 allergens obtained from Hermal company. Results: 240 positive reactions observed i...

BACKGROUND Osteochondroma is the most common non-malignant tumour of bone, accounting for approximately one third of benign lesions in the skeleton. They often develop around the knee in the distal femur and in the proximal tibia and fibula. They present as a painless slow growing mass during adolescence and have been reported to cause damage to adjacent structures such as blood vessels; arteri...

The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome engineering.

BACKGROUND Health economic analysis traditionally relies on patient derived questionnaire data, routine datasets, and outcomes data from experimental randomised control trials and other clinical studies, which are generally used as stand-alone datasets. Herein, we outline the potential implications of linking these datasets to give one single joined up data-resource for health economic analysis...

Budding is a good method of propagation in the Persian walnut (Juglans regia L.)., However, success of budding is low due to higher root pressure as well as the presence of phenolic compounds in the xylem sap. This study was conducted to compare various budding methods and cut below budding union on two and three-year-old Persian walnut under field conditions. The experiment was conducted based...

The nose and upper airways form the initial area of impact for air pollutants and allergens. The development of nasal allergies in the workplace (occupational rhinitis) may herald subsequent development of occupational asthma. Exposure controls, periodic surveillance, and early intervention may circumvent work-related airways disease and prevent unnecessary worker impairment and disability.