Objective: Microbial transformations are green biotechnological processes where different microorganisms, or their enzymes used to produce new metabolites from defined substrates. Hesperidin, quercetin, and derivatives have been proven in scientific research a variety of biological activities such as antioxidant, antimicrobial, anticancer activities. 
 Material Method: transformation hespe...

Targeted therapy has been a very promising strategy of drug development research. Many molecular mechanims of diseases have been known to be regulated by abundance of proteins, such as receptors and hormones. Chemoprevention for treatment and prevention of diseases are continuously developed. Pre-clinical and clinical studies in chemoprevention field yielded many valuable data in preventing the...

Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine. Most studies involving bitter orange extract and p-synephrine have used products with multiple ingredients. The current study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin ...

Present study was designed to evaluate effect Hesperidin on Cardiovascular Complication in isoproterenol induced myocardial infarction in normal and Streptozotocin-Nicotinamide induced in diabetic rats. Hesperidin (100 mg/kg, p.o) was administered for 28 days in rats injected with single dose of Streptozotocin (65 mg/kg, i.p, STZ) and Nicotinamide (110 mg/kg, i.p, NIC) and after isoproterenol (...

T« .HE PRINCIPAL effect of rutin when taken into the body is to restore the strength of the capillary walls when they become weakened. Rutin is a new, cheap, nonpoisonous drug that comes from buckwheat, tobacco, yellow pansies, and at least 35 other plants. Extensive clinical studies of its use in various disease conditions associated with hemorrhage or weak capillaries have demonstrated the va...