Reza Fardid
Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - The effect of Ag NPs co-exposure with UVC irradiation on TK6 cells viability
Introduction: Because of advancement in nanotechnology, the use of Ag Nanoparticles (NPs) was increased in a wide range of area. Studies that were done in recent years demonstrated that Ag NPs can induce cytotoxicity in cells. One of the parts of UV radiation of sun is UVC (200 – 280 nm) that has antimicrobial effect. Since the effect of simultaneous use of NPs and UVC are sti...
[ 2 ] - Expression of phosphorylated histone H2AX in blood lymphocytes of patients undergoing angiographic procedures following exposure to X‐rays
Introduction: Coronary angiography is a Diagnostic-Therapeutic method involving ionizing radiation. This method causes to DNA damage with form double stranded breaks which is followed by the phosphorylation of the histone, H2AX. H2AX is a key factor in the repair process of damaged DNA which will accumulate to damage sites. In human cells, H2AX constitutes about 10% of the H2A ...
[ 3 ] - Assessment of adaptive response of gamma radiation in the operating room personnel exposed to anesthetic gases by measuring the expression of Ku 80, Ligase1 and P53 genes
Introduction: Staffs of operating room are continuously exposed to anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA that causes in the next exposures to higher doses o...
[ 4 ] - Radio-protective effects of Hesperidin against gamma radio-radio-protective effects of Hesperidin against gamma radiation induced histopathological changes in the liver of Sprague Dawely rats
Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to ...
[ 5 ] - The Bystander Effects of Ultraviolet Radiation and Silver Nanoparticles on the H2AX gene expression in TK6 Cells
Introduction: The radiation induced bystander effect (BSE) is the induction of biological changes in unexposed cells, by signals transmitted from bystander cells that cause the spread of radiation toxicity to adjacent or far tissues. In addition, reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as cytokines are involved in mediating mechanisms in bystande...
[ 6 ] - Hesperidin as a natural Radio-Protector
Despite widespread usage of ionizing radiation in medical diagnosis and treatment methods, development of radio-protective agents is important in modulating normal tissue damages. The inherent toxicity of synthetic compounds and the confirmation of low toxicity of natural compound in accordance with long – term usage of medicine have led many researchers to investigate the radio-protective abil...
[ 7 ] - The Bystander Effect of Ultraviolet Radiation and Mediators
A bystander effect is biological changes in non-irradiated cells by transmitted signals from irradiated bystander cells, which causes the radiation toxic effects on the adjacent non-irradiated tissues. This phenomenon occurs by agents such as ionizing radiation, ultraviolet radiation (UVR) and chemotherapy. The bystander effect includes biological processes such as damage to DNA, cell death, ch...
[ 8 ] - Assessment of Adaptive Response of Gamma Radiation in the Operating Room Personnel Exposed to Anesthetic Gases by Measuring the Relative Gene Expression Changes Ku80, Ligase1 and P53
Background: Some operating room personnel are occupationally exposed to genotoxic agents such as anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA (priming dose), which in the subsequent exposure to higher dose of those factors (challenging dose), show more resistance and sensibility.. <b...
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