background: mdm2 (murine double minute2) is an oncoprotein that inhibits the p53 activity. overexpression of mdm2 gene has been reported in several human tumors. in the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of mdm2 and susceptibility to breast cancer in a sample of iranian population. methods: this case-control study wa...

introduction: allocation of the new (expensive) drugs for difficult refractory diseases and financial protection of the patients is an important challenge in the national health systems worldwide especially in developing countries.â  trastuzumab (herceptin) as one of the effective but expensive drugs, put major financial burden for the iranian patients and government. so the ministry of health ...

Our need to create a program for individuals at high risk for breast cancer development led us to research the available data on such programs. In this paper, we summarize our findings and our thinking process as we developed our own program. Breast cancer incidence is increasing worldwide. Even though there are known risk factors for breast cancer development, approximately 60% of patients wit...

OBJECTIVE To screen high-risk population of breast cancer by analyzing the risk factors of breast cancer in Guangdong Province. METHODS A case-control study was performed to identify the risk factors of breast cancer between premenopausal women and postmenopausal women. Chi-square test and unconditional logistic regression were used to analyze the data. RESULTS In premenopausal women, proph...

Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...

Introduction: The purpose of this study was to estimate the secondary cancer risk of thyroid for standard radiotherapy methods which are commonly used for breast cancer patients. Materials and Methods: Sixty-four breast cancer patients (their age range was around 50 years old) who referred to Seyed- Al- Shohada hospital (Isfahan, Iran) were included in this ...

breast cancer is the most common malignancy in women in many parts of the world. the risk factors for breast cancer cover a broad range of conditions, from age to complex genetic alterations. present data is showing an increase in the annual incidence rates of disease and it is ranked as the first recorded malignancies among iranian women after 1999. to study the association of reproductive and...