abstract   introduction: neurodegeneration change is one of the hallmark symptoms of which alzheimer’s disease (ad) can be modeled by β-amyloid injection into specific regions of brain. (-)-epigallocatechin-3-gallate (egcg) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. in the present study, we have wanted to determine whet...

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

Damage to the hippocampus and related brain regions causes a profound amnesic syndrome, in which patients are unable to form new memories about their experiences and about facts about the world. A number of theories have been proposed to explain hippocampal function. The theories that are currently most influential propose that the hippocampus is the substrate of declarative or episodic memory ...

It was found the expression of progesterone receptor membrane component 2 (PGRMC2) in histone epileptic mice lower than that normal mice. In this study, we by immunofluorescence technique, PGRMC2 expressed both astrocytes and neurons mouse hippocampus. addition, seizure latency grade each group were observed after stereotactic injection knockdown virus, overexpression lentivirus, related null v...

Abstract Aberrant neuronal network activity likely resulting from disturbed interactions of excitatory and inhibitory systems may be a major cause cognitive deficits in neuropsychiatric diseases, like within the spectrum schizophrenic phenotypes. In particular, synchrony pattern oscillatory brain appears to limbic networks, e.g. between prefrontal cortex hippocampus. rat model maternal immune a...

Neuroprotective Effects of 1,8-Cineole on Apoptosis Inhibition and Bcl-2/Caspase-3 mRNA Expression in the Hippocampus Epileptic Pilocarpine Model Rats

objective(s): quinolinic acid (qa)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. recent studies suggested that saffron (crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. the present study aimed to investigate th...

different treatment strategies of alzheimer's disease (ad) are being studied for treating or slowing the progression of ad. many pharmaceutically important regulation systems operate through proteins as drug targets. here, we investigate the drug target proteins in beta-amyloid (aβ) injected rat hippocampus treated with lavandula angustifolia (la) by proteomics techniques. the reported stu...