In order to study the response of a poorly differentiated tumor to nutritional manipulation, the Yoshida ascites hepatoma (AH 130) was grown in rats fed an essential fatty acid (EFA)-deficient diet and in rats fed a control diet. Hepatomas, livers, and blood plasma from host rats and normal rats were studied as to the effects of EFA deficiency on the lipid composition. Normal rats fed an EFA-de...

Rapidly growing evidence suggests that complex and variable interactions between host genetic and systems factors, diet, activity and lifestyle choices, and intestinal microbes control the incidence, severity and complexity of metabolic diseases. The dramatic increase in the world-wide incidence of these diseases, including obesity, diabetes, hypertension, heart disease, and fatty liver disease...