Despite their important contribution to the cure of both oncological and benign diseases, gonadotoxic therapies present the risk of a severe impairment of fertility. Sperm cryopreservation is not an option to preserve prepubertal boys' reproductive potential, as their seminiferous tubules only contain spermatogonial stem cells (as diploid precursors of spermatozoa). Cryobanking of human immatur...

Leukocytes, specifically macrophages, lymphocytes and mast cells, are found within the testes of most, if not all, mammals. In some species (for example, rats, mice and humans), the number of 'resident' testicular macrophages, in particular, is quite considerable. However, reproductive biologists are only beginning to explore the characteristics and possible biological significance of these cel...

Background: Saffron consists of dried stigmas and top of the styles of crocus sativus. It has various applications such as sexual potential stimulant, anti spasm, anti depression, sedative ,anti inflammation and anti cancer. Materials and Methods: In present study, 200 male adult rats divided to five groups with 10 rats per each cage and with four replicate for each group. Solvent of saffron wa...

Background & Aim: Onosma stenosiphon has been used as herbal medicine for healing skin cuts and rashes. However, burn healing effect of this herb has not been yet reported in pharmaceutical texts. The aim of this study was to find out the effect of herb ointment on burn healing the superficial wounds post type II burns of back and testis region in Wistar rats. Experimental: A total of...

Background: Giberellic acid is a plant growth regulator,apentacyclicditerpene acid promoting growth and elongation of cells, and also a type of pesticide. In this study its oral administration effect on male rat hormones including gonadotropins (LH and FSH) and testosterone, and also lipid peroxidation product (Malondialdehyde) in testicular tissue was investigated. Materials and Methods: Twent...

Oxidative damage in testicular DNA is associated with poor semen quality, reduced fertility and increased risk of stillbirths and birth defects. These DNA lesions are predominantly removed by base excision repair. Cellular extracts from human and rat testicular cells and three enriched populations of rat male germ cells (primary spermatocytes, round spermatids and elongating/elongated spermatid...

ABSTRACT For a long period, ethno medicinal plants have been a valuable source of natural products for maintaining human health, especially in the last decade, with more intensive studies for natural therapies. The use of ethno medicinal plant for pharmaceutical purposes has gradually increased in Iran. Gundelia tournefortii has been used as an antibacterial, anti-fungal, antipyretic, anti-in...