Dent's disease and familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) are inherited diseases in which hypercalciuria, nephrocalcinosis, and renal failure are prominent features. Dent's disease resembles a Fanconi syndrome, with impaired reabsorption in the proximal tubule; FHHNC, with urinary loss of magnesium and calcium, is associated with impaired cation transport in th...

OBJECTIVE The aim of this study was to determine whether nocturnal enuresis (NE) can be caused by absorptive hypercalciuria. MATERIALS AND METHODS From 1981 to 1995, 406 patients with primary monosymptomatic nocturnal enuresis were studied. Up to 1989 (Group 1), urinary electrolytes and urinary creatinine were not evaluated, but since 1990 (Group 2) these tests have been performed routinely. ...

OBJECTIVE To show the prolonged efficacy of thiazides in the prophylaxis and treatment of recurrences in patients with calcium oxalate and phosphate lithiasis. METHODS A randomised prospective study is conducted, with a three-year follow-up, in 150 patients diagnosed with recurrent calcium lithiasis. The patients are divided into three groups: A) 50 cases subject to observation with no treatm...

Disruption of the major renal Na/phosphate (Pi) cotransporter gene, Npt2a, in mice leads to a substantial decrease in renal brush border membrane Na/Pi cotransport, hypophosphatemia and appropriate adaptive increases in renal 25-hydroxyvitamin D 3-1α-hydroxylase (1αOHase) activity and the serum concentration of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D). The latter is associated with increased in...

Fifteen patients with lymphoma and hypercalcemia (greater than or equal to 11.0 mg/dL) were identified by screening the serum chemistry profile obtained from patients upon admission to the Los Angeles County/USC Medical Center. Seven of the 15 (47%) possessed a frankly elevated serum concentration of 1,25-dihydroxyvitamin D [1,25-(OH)2-D]. An additional patient with severe hypercalcemia (16.2 m...

INTRODUCTION Extracorporeal shock wave lithotripsy (ESWL) is the standard stone treatment. Increased excretion of tubular enzymes and hypercalciuria has been reported after ESWL. We investigated the importance of renally induced hypercalciuria after ESWL. MATERIAL AND METHODS 30 calcium oxalate stoneformers (23 men, 7 women), mean age 53.3 (range 30-71) years, were evaluated prospectively. Pl...

BACKGROUND AND OBJECTIVES Lowe syndrome is defined by congenital cataracts, mental retardation, and proximal tubulopathy and is due to mutations in OCRL. Recently, mutations in OCRL were found to underlie some patients with Dent disease, characterized by low molecular weight proteinuria, hypercalciuria, and nephrocalcinosis. This phenotypic heterogeneity is poorly understood. DESIGN, SETTING,...

After giving oral frusemide (Lasix) to 14 normal volunteers significant hypercalciuria occurred in all of them. This could not be accounted for by any change in glomerular filtration rate, but was possibly due to decreased tubular reabsorption.

Abnormal absorption of dietary calcium has been recognized for many years in intestinal diseases, sarcoidosis (1), idiopathic hypercalciuria (2), hypoparathyroidism (3, 4), hyperparathyroidism (5-7), and more recently in calcinosis universalis (8). Understanding of calcium absorption in the past has been limited by the requirement of 18 to 20 days of metabolic balance procedures; interpretation...