Some commensal intestinal bacteria in humans and mice are coated with secretory immunoglobulin A (S-IgA). It has been suggested that the S-IgA coating of commensal bacteria does not occur at random and thus identification of S-IgA-coated bacterial genera/species should help in elucidating the interaction between S-IgA and commensal intestinal bacteria, but no method of identifying the genera/sp...

Background: IgA nephropathy, a prevalent disease in Asia, is considered the main cause of end stage renal disease among primary glomerular disease. Objective: To determine the frequency of different clinical, histopathological and immunofluorescent characteristics of IgA nephropathy. Methods: Renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. B...

Background: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia among children. Immunoglobulin A is the most numerous immunoglobulin isotype in mucosal secretion.  Immunoglobulin A (IgA) deficiency can increase risk of cancer in patients. Since few studies have been done on relation between serum IgA and ALL, this study was attempted to evaluate serum IgA in ALL patients...

the purpose of this study was to investigate any association between iga deficiency (igad) and juvenile rheumatoid arthritis (jra) among iranian children. this case-control study was carried out on 83 children who were diagnosed as jra according to american college of rheumatology (acr) criteria; patients were admitted at the rheumatology clinic of children's medical center, (tehran). serum imm...

IgA nephropathy (IgAN) is characterized by high serum IgA levels and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils, where present enhancement of IgA production by IgA class switching and immuno-activation. Tripterygium Wilfordii (TW) was found to be especially effective in IgAN by its' immunosuppression effect. Given...

Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood. Objectives: To investigate the changes of the anti-H. py...