Carbodiimide reacts with isocyanide catalyzed by copper(i) iodide, leading to benzoimidazo[1,5-a]imidazoles in good yields. This reaction is efficient, and proceeds through a formal [3+2] cycloaddition and C-N coupling.

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination-cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.

An efficient, simple, and green four-component reaction for synthesizing 1,2,4,5-tetrasubstituted imidazoles is developed. In present work exploring the use of Samarium triflate as a heterogeneous catalyst aldehydes, aromatic amines, benzil, ammonium acetate. The current approach offers many advantages, such excellent yields, shortening time, reusability catalyst, mild conditions.

This is a study of a small group of patients with rheumatoid arthritis, in whom the urine excretion of imidazole compounds was examined by Figlu assay and chromatography of 12-hour urine collections following 15 g. histidine load, and by assay of 4 amino-imidazole-5 carboxamide (AIC) in 12hour urines with and without histidine load. Gough, McCarthy, Read, Mollin, and Waters (1964) found low ser...