نتایج جستجو برای: indomethacin im
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Introduction: One of the surgeries that needs to be considered after pain and discomfort is corneal cross-linking of the cornea. The aim of this study was to compare the effect of indomethacin and acetaminophen oral surgery before surgery on postoperative pain in the patients undergoing collagen cross-linking surgery. Methods: The present study was a double-blind clinical trial study that was ...
Indomethacin-responsive headache syndromes represent a unique group of primary headache disorders characterized by a prompt and often complete response to indomethacin. Indomethacin-responsive headache syndromes are divided into 2 distinct categories in the International Classification of Headache Disorders, 3rd edition (ICHD-3 beta): trigeminal autonomic cephalalgias (paroxysmal hemicrania and...
Polyhydramnios is defined as excessive accumulation of amniotic fluid. It is associated with inceased incidence of abruptio placenta, preterm birth, cord prolopse and neonatal death (30%). So in this clinical trial, 12 pregnant women with significant polyhydramnios (AFI> 24 cm) and gestational age of 24-32 weeks, received oral Indomethacin at a dose of 100 mg/day for 8 days. AF volume decreased...
Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of...
Background & Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. The adverse effects they produce in the gastrointestinal tract however, often limit their utility. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. In view of this, the effect of thyme essential oil, an agent with anti-o...
In recent years, drugs have been identified as newly emerging and threatening the aquatic and terrestrial environments. Accordingly, in this study, the effect of indomethacin on oxidative stress in Cyprinus carpio was investigated. In order to determine the LC50, the fishes were exposed to various concentrations of indomethacin and daily losses were recorded during hours. In the next step, the ...
Indomethacin and other nonsteroidal anti-inflammatory drugs are commonly used to indirectly deduce the possible role of PGs in a process being studied. The objective of this study was to determine if indomethacin, at concentrations comparable to plasma and tissue levels obtained in humans taking therapeutic doses, predisposes human gastric cells to injury through inhibition of PGs or acts throu...
This study was undertaken to examine whether prostaglandin (PG) inhibition with indomethacin interferes with angiotensin II receptor blockade (losartan) during treatment for arterial hypertension. In a double-blind crossover design 10 patients with essential arterial hypertension and treated with losartan were randomized to supplementary treatment with indomethacin or placebo for 1 week, with a...
OBJECTIVE To compare the effectiveness and adverse effects of nifedipine versus indomethacin in the treatment of preterm labor. METHODS In a randomized clinical trial, 79 women with labor pain at 26-33 weeks of gestation were treated with either oral nifedipine (n=40) or rectal indomethacin (n=39). RESULTS Twenty-three (59%) women in the indomethacin group, and 10 (25%) in the nifedipine gr...
In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was extended in the presence of diflunisal. In the presence of indomethacin, the ...
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