نتایج جستجو برای: interferon β
تعداد نتایج: 243008 فیلتر نتایج به سال:
The purpose of this study was to develop a biobetter version of recombinant human interferon-β 1a (rhIFN-β 1a) to improve its biophysical properties, such as aggregation, production and stability, and pharmacokinetic properties without jeopardizing its activity. To achieve this, we introduced additional glycosylation into rhIFN-β 1a via site-directed mutagenesis. Glycoengineering of rhIFN-β 1a ...
Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of pigs. The viral protein Npro of CSFV interferes with alpha- and beta-interferon (IFN-α/β) induction by promoting the degradation of interferon regulatory factor 3 (IRF3). During the establishment of the live attenuated CSF vaccine strain GPE-, Npro acquired a mutation that abolished its capacity to bind and...
Isatis indigotica has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targetin...
Interferon-β (IFN-β) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN-β (ZD55-IFN-β) exhibits significant anti-tumor activities. However, the underlying mechanisms are not clear. Here we showed that ZD55-IFN-β infection-induced S-phase cell cycle arrest in a p53-dependent...
Abstract There are several disease-modifying therapies (DMTs) used as treatments for multiple sclerosis. Depending on their mechanism, DMTs can increase morbidities of viral infections in patients, including SARS-CoV2 and influenza A virus (IAV). B cell depletion (BCD) with anti-CD20 antibodies interferon-β (IFN-β) two popular MS. BCD increases the morbidity acute whereas antiviral properties I...
Background: Viral infections induce expression of type I interferons (IFNα/β) which result in an antiviral state within cells or animals. However, some viruses, notably influenza viruses (IV), have evolved mechanisms of evasion and blocking of IFN to survive in nature. Swine influenza virus (SIV) can inhibit IFN and as with other IV does it through its NS1 protein, identified as a virulence fac...
Liver steatosis is a common characteristic of obesity and type 2 diabetes, and fatty liver disease is increasingly recognized as a major health burden. Accumulating evidence suggests that β-glycosphingolipids play an important role in insulin sensitivity and thus could affect hepatic steatosis. To determine the effect associated with β-glycosphingolipid-mediated amelioration of liver injury, se...
عاملهای شناختی، شخصیتی و موقعیتی متعددی یافت شده است که می توانند با پرخاشگری ارتباط داشته باشند. فهم چگونگی ارتباط درونی این عاملها برای پیش بینی، سنجش، و درمان پرخاشگری زندانیانی که سابقه رفتارهای پرخاشگرانه را دارند، بسیار اساسی است. پژوهشهای قبلی نقش بالقوه ای را برای توانایی حل مساله اجتماعی بعنوان یک میانجیگر بین تکانشگری و پرخاشگری پیشنهاد کرده اند. ( موران و همکاران، 2002). علاوه بر این...
Background and purpose: Interferon beta-1b recombinant protein is used for reducing the relapse rate and treatment in patients with Multiple sclerosis (MS). In this study, phylogenetic and in silico analysis of interferon beta-1b were conducted by servers and bioinformatics tools to predict its structural potential. Materials and methods: Physiological and physico-chemical characteristics of...
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