OBJECTIVE To compare the incidence of tuberculosis over two years in infants vaccinated at birth with intradermal BCG or with percutaneous BCG. DESIGN Randomised trial. SETTING South Africa. PARTICIPANTS 11,680 newborn infants. INTERVENTIONS Infants were randomised by week of birth to receive Tokyo 172 BCG vaccine through the percutaneous route (n=5775) or intradermal route (n=5905) wit...

BACKGROUND Reversing the effects of facial aging is best accomplished with a combination of techniques. Minimizing the appearance of fine wrinkles is an essential part of treatment, which can involve resurfacing, intradermal filler injections, or a combination of the two. The quest for the ideal filler material is ongoing, but intradermal fat injections can serve as an inexpensive and safe alte...

Nodular fasciitis is a reactive myofibroblastic proliferative lesion frequently misdiagnosed as a sarcoma. Most lesions are located in the subcutaneous tissue of the upper extremities. Rarely, intravascular, intradermal, and cranial variants have been described. Intradermal nodular fasciitis, first reported by Goodlad and Fletcher in 1990, may be confused with fibrohistiocytic tumors because of...

Among the several strategies explored for (1) the enhancement of the immune response to influenza immunization, (2) the improvement of the vaccine acceptability and (3) the overcoming of the egg-dependency for vaccine production, intradermal administration of influenza vaccine emerges as a promising alternative to conventional intramuscular route, thanks to the recent availability of new delive...

The antirabies human diploid cell vaccine produced by 1'Institute Merieux, Lyon, France, was administered intradermally to 35 high-risk volunteers using 0.2-ml amounts and various immunization schedules. Three groups never before vaccinated against rabies developed virus-neutralizing antibodies, the titer of which was dose dependent. A single injection stimulated the formation of antibodies. Fo...

BACKGROUND Five to ten percent of immunocompetent persons fail to develop a protective immune response to hepatitis B vaccination, and are defined non-responders (NR). We investigated the immune response to intradermal hepatitis B vaccination after pre-treatment of the skin with the TLR7 agonist imiquimod. METHODS Twenty-one non-responders (anti-HBs <10 IU/l after at least 6 intramuscular hep...

A fairly prevalent hair issue is androgenetic alopecia. Treatment of this type alopecia can be challenging. The available modalities may not have the same efficacy in different patients. invasive method as intradermal injection treatment more effective and gives better results.