Although influenza vaccines are safe and efficacious, vaccination rates have remained low globally. Today, with the advent of new media, many individuals turn to social media for personal health questions information. However, misinformation may be rife, communications suboptimal. This study, therefore, aimed investigate public messaging related by organizations over Twitter, which a far-reachi...

The recent outbreaks of vaccine-preventable diseases have refocused attention on the threat posed by unvaccinated and undervaccinated individuals.1 Governmentsaroundtheworldhaverespondedbystrengthening laws and policies directed at increasing vaccination rates. The standard menu of options includes education and information initiatives, incentives, and mandates; thesemay be directed at the gene...

BACKGROUND Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of cytokine signaling whose expression is induced in the rat heart by cardiotrophin-1 (CT-1). Sepsis-induced myocardial depression results from the expression of inducible nitric oxide synthase (iNOS) evoked by inflammatory cytokines. METHODS AND RESULTS The effect of CT-1 on lipopolysaccharide (LPS)-induced cardiac...

Purpose: p27(p27) is a universal cyclin-dependent kinase inhibitor that inhibits cell cycle transition from G1 to S phase and is primarily regulated at the post-transcriptional level via the ubiquitin-proteasome pathway. In vitro data suggest that p27 degradation may be accelerated by the c-Jun activation domain binding protein-1 (JAB1), originally identified as a coactivator of the gene regula...

With the emergence of COVID-19, many governments around world co-oped non-health actors into enforcing comprehensive mandatory vaccination policies. Implementing these policies can be challenging, creating irreconcilable goals and problems with knowledge understanding areas outside implementers’ direct field expertise or scope work. We know very little about how such frontline workers cope chal...

Frenzied executives who fidget through meetings, lose track of their appointments, and jab at the "door close" button on the elevator aren't crazy--just crazed. They suffer from a newly recognized neurological phenomenon that the author, a psychiatrist, calls attention deficit trait, or ADT. It isn't an illness; it's purely a response to the hyperkinetic environment in which we live. But it has...

The compounding of Total Parenteral Nutrition (TPN) formulations in hospital pharmacies needs a high quality analytical control due to the risk incurred by the patient [1]. Errors in the electrolyte concentrations can lead to important damages on health patient, especially for babies, in neonatology services. For babies and children, some hospitals used commercial TPN but others preferred Indiv...

The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine pathways, particularly the receptor-associated tyrosine kinase/signal transducer and activator of transcription (Jak/STAT) pathways of transcriptional activation. SOCS-1 (also known as JAB and SSI-1) inhibits signaling by many cytokines. Because of the previously obs...

We have recently shown that, in human neutrophils, interleukin-10 (IL-10) fails to induce specific DNA-binding activities to the gamma-interferon response region (GRR), a regulatory element located in the FcgammaRI gene promoter, which is required for transcriptional activation by IL-10 and interferon gamma (IFNgamma) in monocytic cells. In this study, we report that IL-10 is also unable to ind...

At the current stage of genetic studies cattle, more and attention is being drawn to autochthonous breeds. Native cattle have a number prominent phenotypic traits preserved unique genes their combinations lost by modern commercial breeds, which would be valuable use in selective programs. We surveyed polymorphism Ukrainian Gray breed according alleles exon 2 BoLA-DRB3 gene. The uniqueness gene ...