نتایج جستجو برای: jab
تعداد نتایج: 188 فیلتر نتایج به سال:
It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular mechanism of regulation of IFN signaling has not been fully understood. We have reported novel cytokine-inducible SH2 protein (CIS) and JAK binding protein (JAB) family genes that can potentially modulat...
JAB/suppressor of cytokine signaling 1 (SOCS1) STAT-induced STAT inhibitor-1 (SSI-1) (JAB/SOCS1/SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. The role of JAB/SOCS1/SSI-1 in IL-2 signaling has been analyzed. JAB/S...
JAB/suppressor of cytokine signaling 1 (SOCS1) STAT-induced STAT inhibitor–1 (SSI-1) (JAB/SOCS1/SSI-1) is an SH2domain–containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-g, prolactin, growth hormone, and erythropoietin. The role of JAB/SOCS1/SSI-1 in IL-2 signaling has been analyzed. JAB/ SOCS1...
It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular mechanism of regulation of IFN signaling has not been fully understood. We have reported novel cytokineinducible SH2 protein (CIS) and JAK binding protein (JAB) family genes that can potentially modulate...
The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth, differentiation and transformation through their association with cytokine receptors. However, compared with other kinases, little is known about cellular regulators of the JAKs. We have recently identified a JAK-binding protein (JAB) that inhibits JAK signaling in cells. In the studies pres...
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription (STAT) transcription factors. We recently identified two intrinsic Janus kinase (JAK) inhibitors, JAK binding protein (JAB; also referred to as supp...
Jackknife-after-Bootstrap (JaB) has first been proposed by [1] then used by [2] and [3] to detect influential observations in linear regression models. In this study, we propose using JaB to detect influential observations in logistic regression model. Performance of the proposed method will be compared with the traditional method for standardized Pearson residuals, Cook’s distance, change in t...
Antarctic summer saw the largest ship ever visit Antarctica: the Star Princess with 3,500 passengers and crew sailed amongst humpback whales and colonies of gentoo penguins. But, at a meeting this month in New Zealand of the treaty nations, several regulations are expected to be tightened for the southern high latitudes with knock-on effects for the Arctic. The meeting may also finally prohibit...
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