BACKGROUND Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities. METHODS Data from two parallel, multicenter traumatic hemorrhagic shock clinical trials from 17 US Emergency Departments and 27 European Union p...

We read with interest the article written by Dr. Lee et al. [1] on renal involvement in Erdheim-Chester disease (ECD). We agree with the authors on the long asymptomatic period of obstructive nephropathy that occurs in ECD. In our experience, a 60-year-old female, suffering from diabetes mellitus, who was treated with metformin, was admitted for fever, abdominal pain, diarrhoea, and acute renal...

Abstract Clinical case A 69–year–old man with right shoulder discomfort, malaise for one hour and hemodynamic instability was admitted to our Emergency Department (ED). The patient had a history of arterial hypertension, diabetes, renal failure on peritoneal dialysis ischemic cardiomyopathy preserved ejection fraction treated by angioplasty stent implantation coronary. At first medical contact ...

Since anaerobic glycolysis yields two lactates for each glucose consumed and since it is reported to be a major source of ATP for inner medullary (IM) cell maintenance, it is a likely source of "external" IM osmoles. It has long been known that such an osmole source could theoretically contribute to the "single-effect" of the urine concentrating mechanism, but there was previously no suggestion...

Certain of the metabolic events associated with anaerobic sodium transport by the isolated bladder of the fresh water turtle have been investigated. The data suggest that energy for this transport arises from glycolysis and that endogenous glycogen was the major and perhaps the sole source of substrate. The rate of anaerobic glycolysis, as determined by lactate formation, correlates well with t...

BERNANKE, DAVID, AND FRANKLIN H. EPSTEIN. Metabolism of the renal medulla. Am. J. Physiol. 208(3): 5p-545. Ig65.Slices of the inner medulla of kidneys removed from hydropenic dogs were incubated with glucose and succinate under aerobic and anaerobic conditions. When theoretical maximum ATP generation was calculated from oxygen uptake and lactate production, the calculated energy production from...

• Early studies of the effects of epinephrine on the isolated and metabolically supported canine heart demonstrated increases in heart rate, contractile force, and myocardial oxygen consumption. The increases in myocardial oxygen consumption following epinephrine administration were roughly proportional to the increase in heart rate. In heart-lung preparations epinephrine administration resulte...