introduction: sexhormones are one of most important factors in difference of learning and memory between tow sexes (male & female). high concentration of estrogen and androgen receptors and mechanism of testosterone and estrogen production in learning and memory center, especially in hippocampus show the role of this receptors, sexhormons and p450 enzymes in spatial memory. consequently, in thi...

introduction: ascorbic acid (aa) acts as an antioxidant in the central nervous system (cns) of the mammalians. it is released from the some nerve ending together with neurotransmitters. the results have shown that ascorbic acid could affect learning as well as memory. in this study, we examined the effect of icv injection of ascorbic acid on learning and memory by morris water maze. method: in ...

background: different stressors induce learning and memory impairment and physical activity influence learning and memory enhancement. in this research, we investigated the effect of synchronized running activity with stress on acquisition and retention time of passive avoidance test. methods: male wistar rats were randomly divided into five groups as follows: control (co), sham (sh), exercise ...

Introduction: Estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs patient memory. The human nucleus basalis of Meynert (nBM) is severely affected in Alzheimer's disease. So in this study the effect of peripheral (intramuscul...

Introduction: Psychomotor performance task is used to assess the arousal and cognitive functions of the central nervous system. Alternatively, human visual working memory reflects the capability of the individual’s short-term memory. Psycho-mental stimuli are linked to the stimulation of Malondialdehyde (MDA) formations. Citicoline is a nootropic nucleotide agent with a favorable effect on the ...

melissa officinalis l. (labiatae) traditionally used in treating neurological disorders has also been identified as a memory-enhancing herb. the extract of m. officinalis has a cholinergic property. the role of basal forebrain cholinergic neurons, the neurons that are destroyed in alzheimer’s disease (ad), in learning and memory, is also well known. the aim of this study is to investigate the r...