BACKGROUND The impact of transoral endoscopic CO(2) laser microsurgery (TLM) for the treatment of Tis, T1, and T2 glottic cancer on local disease control, survival, and laryngeal preservation was investigated. METHODS From October 1999 to February 2008, 48 patients with a previously untreated early laryngeal malignant tumor who had been treated with TLM were enrolled in this study. Overall su...

Vocal fold scarring is a predominant cause of voice disorders yet lacks a reliable treatment method. The injection of soft biomaterials to improve mechanical compliance of the vocal folds has emerged as a promising treatment. Here, we study the use of precise femtosecond laser microsurgery to ablate subsurface voids, with a goal of eventually creating a plane in dense subepithelial scar tissue ...

BACKGROUND The objective of this study was to evaluate the outcomes of transoral laser microsurgery (TLM) in T3 laryngeal carcinomas and to identify prognostic factors for survival and laryngeal preservation. METHODS This study aimed to provide a retrospective analysis of 147 consecutive patients, evaluating their overall survival, disease-specific survival, laryngectomy-free survival, and fu...

In recent years, surgical treatment of laryngeal cancer has evolved towards transoral resections. Transoral laser microsurgery (TLM) combines microscopic control with the precise cutting and coagulation capability that laser equipment has, making it possible to remove laryngeal tumours by the transoral approach, with very good oncological and functional outcomes. In early tumours, local control...

We investigated the forces that connect the genetic program of development to morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for development and wound healing. We found that the bulk of progress toward closure is driven by contractility in supracellular "purse strings" and in the amnioserosa, whereas adhesion-mediated zipping coordinates the forces produced b...

results the mean follow-up duration was 34 ± 23 months. the q-dash scores improved from 70 ± 6 points preoperatively to 13 ± 15 points at final follow-up (p < 0.01). the preopetative range of motion (rom) was 101 ± 26 degrees; whereas the final forearm rom was 140 ± 17 (p = 0.01). all non:union:s united uneventfully (range 3-6 months). at the last follow-up, the grip force was 83% of uninjured ...

INTRODUCTION Clinicians are regularly confronted with difficult choices. Should a tooth that has not healed through nonsurgical root canal treatment be treated through endodontic microsurgery or be replaced using a single implant? Acquiring complete, unbiased information to help clinicians and their patients make these choices requires a systematic review of the literature on treatment outcomes...

OBJECTIVES/HYPOTHESIS To demonstrate that reconstructive transoral laser microsurgical (R-TLM) techniques can be used for the treatment of symptomatic laryngeal posterior glottic web-based stenosis (PGWS) in a large cohort of patients utilizing a postcricoid mucosal advancement flap (PCMAF). STUDY DESIGN Retrospective cohort review. METHODS A consecutive series of patients with PGWS who und...

This study combines microfluidics with optical microablation in a microscopy system that allows for high-throughput manipulation of oocytes, automated media exchange, and long-term oocyte observation. The microfluidic component of the system transports oocytes from an inlet port into multiple flow channels. Within each channel, oocytes are confined against a microfluidic barrier using a steady ...