OBJECTIVE To determine the effect of carbon dioxide laser microsurgery in the treatment of intractable chronic myringitis (CM). DESIGN Retrospective 10-year case note review. SETTING Tertiary referral hospital. PATIENTS We reviewed retrospective case notes for 30 treated ears in 29 consecutive patients with CM (ie, loss of the tympanic membrane for longer than 1 month, refractory to conse...

BACKGROUND The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early larynx cancer. However, at the forefront of early glottis treatment is trans-oral laser microsurgery and radiation therapy, likely due to better functional and survival outcomes. H...

Femtosecond laser microsurgery has become an advanced method for clinical procedures and biological research. The tissue treated by femtosecond laser can become highly fluorescent, indicating the formation of new fluorescent compounds that can naturally label the treated tissue site. We systematically characterized the fluorescence signals produced by femtosecond laser ablation in biological ti...

BACKGROUND The purpose of this study was to investigate oncological and functional results of enoral laser microsurgery in treatment for cancer of the oral cavity. METHODS A retrospective chart analysis was carried out. Two hundred thirty-two patients with cancer of the oral cavity were treated by enoral laser microsurgery ± selective neck dissection ± postoperative (chemo)radiotherapy. RES...

BACKGROUND Although already established for treatment for early-stage laryngeal cancers, transoral laser microsurgery indications for more advanced tumors are not unanimous. Additionally, no outcomes concerning the Portuguese population are currently accessible. METHODS Outcomes of 248 patients presenting laryngeal carcinoma primarily treated by transoral laser microsurgery with curative inte...

The aim of the present study was to evaluate the oncological efficacy of salvage total laryngectomy in patients who had previously undergone supracricoid partial laryngectomy or transoral laser microsurgery for treatment of laryngeal squamous cell carcinoma. We retrospectively reviewed the medical, surgical and pathological records of 35 patients who underwent salvage total laryngectomy after r...

Vocal fold scarring can arise from disease or postsurgical wound healing and is one of the predominant causes of voice disorders. Focused ultrafast laser pulses have been previously demonstrated to create tightly confined sub-surface ablation in a variety of tissue, including vocal folds. Here, we demonstrate how we can take advantage of this unique ability of ultrafast laser ablation to create...

BACKGROUND Transoral laser microsurgery is successfully performed in the treatment of primary laryngeal carcinomas. Few publications deal with the application in patients with recurrent glottic carcinomas after radiation failure. Our study aims to review our experience with transoral laser microsurgery in these patients. METHODS Thirty-four patients with early and advanced recurrent glottic c...

We use a spatial light modulator (SLM) to diffract a single UV laser pulse to ablate multiple points on a Drosophila embryo. This system dynamically generates a phase hologram for ablating a user-defined pattern fast enough to be used with living, and thus moving, tissue. We demonstrate the ability of this single-pulse multi-point system to perform two experiments that are very difficult for co...