To obtain efficient estimation of parameters is a major objective in population pharmacokinetic study. In this paper, we propose an empirical likelihood-based method to analyze the population pharmacokinetic data based on the generalized linear model. A nonparametric version of the Wilk’s theorem for the limiting distributions of the empirical likelihood ratio is derived. Simulations are conduc...

Several new tests are proposed for examining the adequacy of a family of parametric models against large nonparametric alternatives. These tests formally check if the bias vector of residuals from parametric Ž ts is negligible by using the adaptive Neyman test and other methods. The testing procedures formalize the traditional model diagnostic tools based on residual plots. We examine the rates...

In many situations, data follow a generalized partly linear model in which the mean of the responses is modeled, through a link function, linearly on some covariates and nonparametrically on the remaining ones. A new class of robust estimates for the smooth function η, associated to the nonparametric component, and for the parameter β, related to the linear one, is defined. The robust estimator...

Hierarchical linear models with a block circular covariance structure are considered. Sufficient conditions for obtaining explicit and unique estimators for the variance-covariance components are derived. Different restricted models are discussed and maximum likelihood estimators are presented.

Canonical generalized linear models (GLM) are specified by a finite dimensional vector and a monotonically increasing function called the link function. Standard parameter estimation techniques hold the link function fixed and optimizes over the parameter vector. We propose a parameter-recovery facilitating, jointly-convex, regularized loss functional that is optimized globally over the vector ...

This paper develops an MILP model, named Satisfactory-Green Vehicle Routing Problem. It consists of routing a heterogeneous fleet of vehicles in order to serve a set of customers within predefined time windows. In this model in addition to the traditional objective of the VRP, both the pollution and customers’ satisfaction have been taken into account. Meanwhile, the introduced model prepares a...

An approach to deal with the phenomenon of maritime fuel smuggling is to control the quantity of fuel that is supplied to vessels. For the same reason, fuel is delivered to marine vessels in Iran in accordance with the ration defined by the National Iranian Oil Products Distribution Company (NIOPDC). The ration is determined by a fuel consumption formula defined by the Food and Agriculture Orga...