Liposomes are spherically shaped phospholipid bilayers that used to encapsulate hydrophilic or lipophilic drugs. To have efficient drug delivery by a liposome, it should be able deliver the specific binding site, where can affect target. However, sometimes, due untimely release, this goal cannot achieved. Therefore, permeation rate of through liposomal membrane is important, as affects drug’s r...

The dynamics of liposome solubilization was monitored by dynamic light scattering and optical microscopy. A newly designed Y-shape microchannel connected to a room was incorporated into a microchip and the reaction processes of the liposome suspension and surfactant solution were observed in the room after mixing the two fluids and stopping the flow. By using this microchip, we succeeded in r...

We developed selective transfection of single particle sensor into a specific cell by optically controlled cell immobilization and membrane fusion of liposome for intracellular measurement. The particle was encapsulated in the liposome using packaging based on multi-layering method. The liposomes contain 1,3,3-Trimethylindolino-6'nitrobenzopyrylospiran (SP) that controls the surface potential o...

Nanoliposome can be designed as a drug delivery carrier to improve the pharmacological and therapeutic properties of drug administration. (188)Re-labeled nanoliposomes are useful for diagnostic imaging as well as for targeted radionuclide therapy. In this study, the in vivo nuclear imaging, pharmacokinetics and biodistribution of administered nanoliposomes were investigated as drug and radionuc...

Cyclodextrins (CDs) can form polypseudorotaxanes (PPRXs) with drugs or drug carriers possessing linear polymers such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier. However, little is known about the formation of CD PPRX with PEGylated liposome. In the present study, we first report the formation of CD PPRX wit...

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step.

  Objective(s): Soluble Leishmania antigens (SLA) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. Liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-A (PLA) activity of SLA is a drawback to prepare a stable liposomal SLA. One strategy to overcome this problem migh...

After extensive work spanning more than half a century, liposomes have crossed the chasm and emerged as prominent candidate in mainstream drug delivery. Post historic launch of first liposome-based drug, it is last three decades when liposome technology has slowly transformed from research apparatus to versatile carrier system influencing many biomedical areas. Liposomes ability deliver target ...