BACKGROUND Parenteral nutrition-associated liver disease can be a progressive and fatal entity in children with short-bowel syndrome. Soybean-fat emulsions provided as part of standard parenteral nutrition may contribute to its pathophysiology. METHODS We compared safety and efficacy outcomes of a fish-oil-based fat emulsion in 18 infants with short-bowel syndrome who developed cholestasis (s...

Background: Rosmarinus officinalis is a useful medicinal plant with numerous ethnopharmacological applications and widespread use in the industry. The main constituent of this plant is essential oil. There is a misconception that there is no restriction to using medicinal plants. The present study examined the effects of the chronic administration of Rosemarinus officinalis essential oil on the...

In 1934 Lohr’ reported the external use of cod liver oil in the treatment of skin wounds. Recently, “A Status Report on the External Use of Cod Liver Oil”2 summarized the Literature. Many other conditions have also been treated according to the same principles. To this subj ect we would like to add the following: We proceeded to inject intra-pleurally, considering it as a topical application, a...

Malignant transformation of hepatocellular carcinoma (HCC) occurs through repetitive liver injury in a context of inflammation and oxidative DNA damage. A spectrum of natural sesquiterpenoids from curcuma oil has displayed antioxidant, anti-inflammatory and anti-carcinogenic properties. The aim of the study was to investigate the hepatoprotective and anti-HCC effects of curcuma oil in vivo and ...

background: finding protective agents with fewer adverse effects against toxin-induced liver injuries, as a key detoxifier and excreter organ, have always been a concern for researchers. carbon tetra-chloride (ccl4)-induced liver damage has been introduced as an experimental model of liver damage. this study aimed to investigate the protective effect of ethanolic extract of zizyphus vulgaris (z...

The obesity epidemic in the U.S. has led to extensive research into potential contributing dietary factors, especially fat and fructose. Recently, increased consumption of soybean oil, which is rich in polyunsaturated fatty acids (PUFAs), has been proposed to play a causal role in the epidemic. Here, we designed a series of four isocaloric diets (HFD, SO-HFD, F-HFD, F-SO-HFD) to investigate the...

Rats were fed a purified diet containing either 1.5% sunflower oil [940 mg linoleic acid [18:2(n-6)]/100 g diet; 6 mg alpha-linolenic acid [18:3(n-3)]/300 g diet] or 1.9% soybean oil [940 mg 18:2(n-6)/100 g diet; 130 mg 18:3(n-3)/100 g diet]. In all cases and tissues examined 22:6(n-3) was lower and 22:5(n-6) was higher in rats fed sunflower oil than in rats fed soybean oil. Levels of 22:4(n-6)...

OBJECTIVE Parenteral nutrition in infants with gastrointestinal disorders can be lifesaving, but it is also associated with parenteral nutrition-associated liver disease. We investigated the effects of incorporating ω-3 fish oil in a parenteral nutrition mixture on signs of parenteral nutrition-associated liver disease and explored the mechanism involved in this process. METHODS Seven-day-old...

Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) exert health benefits which are dependent upon their incorporation into blood, cells and tissues. Plasma and tissue deposition of LC n-3 PUFA from oils extracted from the micro-algae Nannochloropsis oculata and from krill were compared in rats. The algal oil provides eicosapentaenoic acid (EPA) partly conjugated (15%) to phospholipids...

Published data assessing the efficacy and toxicity of omega-3 fatty acid emulsion in children are limited. Until recently, children requiring long-term parenteral nutrition who experienced parenteral nutrition–associated liver disease (PNALD) were likely to die from infection or liver disease before receiving a small bowel and/or liver transplant. With the introduction of parenteral fish oil (1...