Parkinson's disease (PD) is linked to the formation of insoluble fibrillar aggregates of the presynaptic protein α-Synuclein (αS) in neurons. The appearance of such aggregates coincides with severe motor deficits in human patients. These deficits are often preceded by non-motor symptoms such as sleep-related problems in the patients. PD-like motor deficits can be recapitulated in model organism...

s | 27 Results: Social defeat stress as juveniles, even with 1-day exposure, induced robust and persistent deficits of social behaviors in relation to the unfamiliar ICR mouse, compared with the responses of mice exposed to the stress as adults. The stress did not affect anxiety-like behaviors during spontaneous locomotor activity in a novel environment and performance on the elevated plus-maze...

The study purpose was to determine a survey of basic locomotor, non-locomotor, and manipulative movement skills in elementary school students Kecamatan Kandangan Kabupaten Kediri East Java the midst COVID-19 pandemic. 
 Materials methods. This used descriptive research design with quantitative type, for method this method. population 2997 students. Determination sample size Accidental purp...

The cognitive impairment in Alzheimer's disease (AD) may be associated with deficits in walking and a higher incidence of falls in this population. The aim of the study was to analyze the relationship among cognitive aspects and walking parameters. The correlation between clinical variables and stride length found in this study suggest the involvement of the cortex on walking. The deterioration...

Spinal cord injury (SCI) often leads to persistent functional deficits due to the loss of neurons and glia and to limited axonal regeneration after such injury. Recently, three independent groups have reported marked recovery of hindlimb locomotor function after the transplantation of human adult dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) into ra...

Mitochondrial dysfunction is increasingly being recognized as a therapeutic target in PLA26G-associated neurodegeneration (PLAN). We demonstrated in Drosophila and in human PLA2G6 mutant fibroblasts that loss of normal PLA2G6 activity is associated with increased mitochondrial lipid peroxidation and mitochondrial dysfunction. Furthermore, we identified the therapeutic benefits of deuterated pol...

1. Vestibular compensation was studied in goldfish that had had the utriculus and semicircular canal organs unilaterally removed. Characteristic postoperative behavioural deficits of postural asymmetry were quantitatively scored. Operated animals were compared with those subject to the same duration of anaesthesia and restraint during a sham operation. 2. The period of several minutes following...

Background Familial hypercholesterolemia (FH) is a clinical condition characterized by increased plasma cholesterol levels, due to mutation in the gene encoding low-density lipoprotein receptor (LDLr) cells [Brown and Goldstein, 1984]. Importantly, evidence indicates that FH negatively affects cognition favors development of neuropathologies [Ariza et al., 2016; Zambón al, 2010], however, mecha...

Alternating contractions of antagonistic muscle groups during locomotion are generated by spinal "half-center" networks coupled in antiphase by reciprocal inhibition. It is widely thought that reciprocal inhibition only coordinates the activity of these muscles. We have devised two methods to rapidly and selectively silence neurons on just one side of Xenopus tadpole spinal cord and hindbrain, ...

methamphetamine (ma) is a potent, addictive psychostimulant that has dramatic effects on the central nervous system (cns). the onset of methamphetamine use has been linked to heightened attention, and chronic methamphetamine use has been associated with deficits in different aspects of attention that can significantly persist into abstinence. attention deficits in chronic methamphetamine users ...