OBJECTIVE To analyze morphological macular changes after uncomplicated cataract surgery and their correlation with age and arterial hypertension. METHODS Total macular volume (TMV), foveal volume (FOVOL) and foveal thickness (FOV) in patients who had undergone cataract surgery were measured using OCT3 Stratus before surgery, the day after the intervention and one month later. The data were an...

Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans. Methods. Thirty-six consecut...

Parkinson's disease (PD) is characterized by motor and nonmotor symptoms. Nonmotor symptoms include primarily visual hallucinations (VH). The aim of our study was to establish whether patients with PD and visual hallucinations (PDH+) have structural changes of retina detected by an optical coherence tomography (OCT) in comparison with PD patients without visual hallucinations (PDH-). We examine...

INTRODUCTION Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated. Previous reports have shown that this affects the grey matter of the primary visual cortex, but possible effects on the preceding visual pathway structures have not been fully established. METHODS In this multicentre...

This article reviews the current state of knowledge about the bestrophins, a newly identified family of proteins that can function both as Cl(-) channels and as regulators of voltage-gated Ca(2+) channels. The founding member, human bestrophin-1 (hBest1), was identified as the gene responsible for a dominantly inherited, juvenile-onset form of macular degeneration called Best vitelliform macula...

PURPOSE Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). METHODS On this transversal, observational study, 300 patients between 18 to 87 years old and without an ophthalmological condition were recruited. Macular OCT scans we...

Background The retina, an extension of the central nervous system, shows promise for development non-invasive, low cost AD risk screening biomarkers. Most studies do not answer question whether retinal biomarkers are useful in pre-symptomatic phase assessment early disease risk. In this study1, we investigated structural changes neural layers between and high cognitively unimpaired (CU) older a...

We aimed to determine normal macular thickness using Cirrus high definition optical coherence tomography. In this cross-sectional survey, 112 subjects were selected using random sampling from the Rasht telephone directory. All subjects underwent complete eye examinations. Both eyes of each patient were evaluated. The creation of a macular thickness map using a macular cube 512 × 128 combo was o...

Assessment of the peripapillary nerve fiber layer and macular thickness can be determined in ophthalmology using optical coherence tomography (OCT). Decreased nerve fiber layer thickness and macular ganglion cell thickness in optic nerve ischemia have been correlated with visual field loss. OCT allows deep optic nerve head evaluation which helps understand pathophysiology of diseases.  Furtherm...