Abstract Gut microbiota is now recognized as a key player impacting the host’s anti-cancer immunosurveillance and ability to respond immunotherapy. Its optimal modulation for preventive therapeutic purposes very appealing. Since diet one of most powerful modulators microbiota, nutritional interventions could be leveraged improve host immunity. The present study aims analyze anticancer propertie...

auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. in the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...

background: leishmaniasis is a tropical disease that is endemic in some areas of iran, including east azerbaijan . ifn-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. this case-control study was performed to investigate the association between the polymorphism of the ifn-γ gene at the +874a/t locus and visceral leishmaniasis (vl). me...

All jawed vertebrates (Gnathostomes) possess a complex immune system, which is capable of adaptive (anticipatory) and innate (natural) immune responses(1,2). In contrast, jawless vertebrates (Agnathes) and invertebrates lack an adaptive immune response and its defence depends exclusively on the innate immunity (Fig. 1). The coordination of adaptive and innate immune responses is largely mediate...