OBJECTIVES To compare extracellular and intracellular activities of telavancin (versus vancomycin) against Staphylococcus aureus (MSSA, MRSA, VISA and VRSA). METHODS Determination of cfu changes (3-24 h) in culture medium and in macrophages at concentrations ranging from 0.01 to 1000x MIC. RESULTS Extracellularly, telavancin displayed a fast, concentration-dependent bactericidal activity ag...

1. Vandenesch F, Naimi T, Enrigth MC, Lina G, Nimmo GR, Herffernan H, et al. Community-acquired methicillin-resistant Staphylococcus aureus carrying PantonValentin leuckocidin genes: worldwide emergence. Emerg Infect Dis. 2003;9:978–84. 2. Maltezou HC, Giamarellou H. Communityacquired methicillin-resistant Staphylococcus aureus infections. Int J Antimicrob Agents. 2006;27:87–96. 3. Zetola N, Fr...

Background & Aims of the Study: Methicillin-resistant staphylococcus aureus (MRSA) is considered as a major pathogen in public health concern. The objectives of this study were to firstly determine antibiotic sensitivity among Staphylococcus aureus isolated from traditional Iranian white cheese during 2015 from Hamedan province of Iran; and secondly to estimate the presence of ...

Introduction / objectives We assessed the usefulness of a new automated molecular assay (GenomEra MRSA Confirm, Abacus Diagnostica Oy, Finland), which amplifies simultaneously the marker of methicillin resistance (mecA) and a Staphylococcus aureus-specific DNA segment, in detection of methicillin sensitive and resistant S. aureus (MSSA and MRSA) and other methicillin resistant staphylococci (MR...

1. Crnich CJ, Drinka P. Predicting the impact of contact precautions on methicillin-resistant Staphylococcus aureus outcomes: caution up ahead. Infect Control Hosp Epidemiol 2013;34(6):646-647 (in this issue). 2. Lee BY, Singh A, Bartsch SM, et al. The potential regional impact of contact precaution use in nursing homes to control methicillinresistant Staphylococcus aureus. Infect Control Hosp ...

Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

We report here the complete genome sequence of the livestock-associated methicillin-resistant Staphylococcus aureus strain 08S00974 from sequence type 398 (ST398 LA-MRSA) isolated from a fatting pig at a farm in Germany.

INTRODUCTION Community-acquired methicillin-resistant Staphylococcus aureus infections are a common, serious problem in pediatrics. OBJETIVE To describe antibiotic resistance in community-acquired Staphylococcus aureus (SA) bacteremias. To compare the characteristics of SA bacteremias in terms of methicillin resistance. MATERIALS AND METHODS Prospective cohort enrolled between January 2010 ...

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) ST398 isolated from pigs raised in conventional farms was previously reported. Here we report a study on 25 farms adhering to an alternative system. LA-MRSA ST398 was not detected in nasal swabs from 178 pigs or from 89 humans working and living on these farms.