background: treatment of cesarean scar pregnancy (csp) is controversial. the objective of this study was to report our successful experience in the medical treatment of csp with potassium chloride (kcl) and methotrexate. case: this is a case series of six patients between 6-12 gestational weeks with the diagnosis of csp.  in five cases the fetus was alive and in one case, despite being at a ges...

Mycosis fungoides (MF) and its leukemic variant Sézary syndrome (SS) comprise the majority of CTCL, a heterogenous group of non-Hodgkins lymphomas involving the skin. The CTCL's resistance to chemotherapy and the lack of full understanding of their pathogenesis request further investigation. With the view of a more targeted therapy, we evaluated in vitro the effectiveness of bortezomib and meth...

Immunosuppressant drugs, such as methotrexate, are able to inhibit cytokine production and leukocyte migration to inflammatory foci; therefore, they could modify the establishment of inflammation in adipose tissue during obesity. Thus, we studied the effects of methotrexate in vivo on high-fat diet induced-obesity in mice and in vitro in isolated and co-cultured adipocytes and macrophages. Obes...

Osteosarcoma is the most common primary bone tumor in children and young adults. The median survival of osteosarcoma patients has not significantly improved since 1990, despite administration of different classes of chemotherapy agents, such as methotrexate, cisplatin and doxorubicin. Cancer stem cells (CSCs) are responsible for the resistance of osteosarcoma to chemotherapy and OCT4, SOX2 and ...

cesarean scar pregnancy (csp) is a rare, but life-threatening type of ectopic pregnancy. an exact and early diagnosis of csp is very important for prognosis. the aim of the present study was to describe 4 women with csp and discuss their clinical presentations, diagnoses, and various management options along with the published literature. four women with a suspicion of csp or cervical pregnancy...

background : gestational trophoblastic neoplasia (gtn) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. even in its metastatic forms gtn is curable with a cure rate of 90-100 %. currently, methotrexate with or without folic acid, andactinomycin d is recommended for low risk gtn. the aim of this study is to compare the efficacy of methotrexate and acti...

The aim of the review is studying immune response to new coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus in different populations, including those with immunosuppression due concomitant diseases or immunosuppressive therapy. role T cells building up anti-COVID-19 immunity special interest, particularly, when comparing cell and antibody based immunity. A number studies are focused...

Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and cycloguanil have sparked renewed interest in the antimalarial drugs WR99210 and proguanil, the cycloguanil precursor. To investigate suggestions that WR99210 and proguanil act against a target other than the reductase moiety of the P. falciparum bif...